Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3834

Full Length Research Paper

Evaluation of antioxidant effects in vitro of garcinielliptone FC (GFC) isolated from Platonia insignis Mart

J. S. Costa Júnior1,2, A. B. F. Ferraz1, B. A. B. Filho2, C. M. Feitosa2, A. M. G. L. Citó3, R. M. Freitas3* and J. Saffi4
1Laboratory of Genetic Toxicology, Post-Graduation Program in Genetic and Applied Toxicology, Lutheran University of Brazil; zip code 92425-900, Canoas, RS, Brazil. 2Department of Chemistry, Federal Institute of Piaui, zip 64000-040, Teresina, PI, Brazil. 3Post-Graduation Program in Pharmaceutics Science, Federal University of Piaui, zip code 64049-550, Teresina, PI, Brazil. 4Department of Basic Health Sciences – Federal University of Health Sciences of Porto Alegre, zip code 90050-170, Porto Alegre, RS, Brazil.
Email: [email protected]

  •  Accepted: 25 November 2010
  •  Published: 18 January 2011

Abstract

The antioxidant effects of garcinielliptone FC (GFC) isolated from the seeds of Platonia insignis were assessed in vitro tests (thiobarbituric acid reactive species (TBARS) assay, hydroxyl radical-scavenging activity, and scavenging activity of nitric oxide (NO)). GFC was identified by analysis of spectroscopic data. GFC prevented oxidative damage to lipids induced by a free radical source in vitro (AAPH) and showed antioxidant potential against two different reactive species in vitro. GFC in high dose demonstrated to exert a significant scavenging effect against NO and hydroxyl radicals generated in vitro. In conclusions, our results support that GFC compound exhibits an antioxidant action.

 

Key words: Platonia insignis, garcinielliptone FC, seeds, antioxidant.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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