Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3823

Full Length Research Paper

Myracrodruon urundeuva bark: an antimicrobial, antioxidant and non-cytotoxic agent

Jannyson José Braz Jandú1, Luís Cláudio Nascimento da Silva2, Aline de Paula Caetano Pereira2, Renata Maria de Souza2, Carlos Alberto da Silva Júnior2, Regina Célia Bressan Queiroz de Figueiredo3, Janete Magali de Araújo4, Maria Tereza dos Santos Correia2 and Márcia Vanusa da Silva1*    
1Department of Biochemistry, Laboratory of Natural Products , Federal University of Pernambuco, Brazil. 2Department of Biochemistry, Laboratório of Glycoproteins, Federal University of Pernambuco, Pernambuco, Brazil. 3Department of Microbiology, Laboratory of Cell Biology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Pernambuco, Brazil. 4Department of Antibiotics, Laboratory of  Genetics of Microorganisms, Federal University of Pernambuco, Pernambuco, Brazil.      
Email: [email protected]

  •  Accepted: 24 October 2012
  •  Published: 25 February 2013


This work evaluated the antioxidant, antimicrobial and cytotoxic activities of Myracrodruon urundeuva methanolic extract (MuBME) and identified its major phenolic compounds. The extract showed activity against all tested microorganisms (MIC: 0.39 to 3.13 mg/mL), and was able to enhance the erythromycin activity against some clinically isolatedStaphylococcus aureus strains: fractional inhibitory concentration indices (ΣFIC) < 1. MuBME also showed a high antioxidant activity with 81.34 ± 0.2% of ascorbic acid activity (in phosphomolybdenum assay) and inhibited H2O2 and DPPH radical (IC50 of 0.038 and 0.0033 mg/mL, respectively). The phenolic and flavanoid content were 37.0 ± 0.47 mg/g gallic acid equivalents (GAE) and 43.88 ± 6.55 quercertin equivalents (QE)/mg, respectively. Additionally, we tested the cytotoxicity and observed IC50 of 1.94 (human erythrocytes) and 1.57 (Vero cells) mg/mL, much higher than the concentrations required for the biological responses tested. Gallic acid, protocatechuic acid, chlorogenic acid, catechuic acid and fumaric acid were detected by Ultra-fast liquid chromatography (UFLC) analysis and they are possible active compounds. Our results showed that M. urundeuvabark exhibits antimicrobial and antioxidant properties with application in pharmaceutical, food and cosmetics industries.


Key words: Caatinga, Myracrodruon urundeuva, antimicrobial, antioxidants, non-hemolytic compounds.