Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3793

Full Length Research Paper

Compounds with elastase inhibition and free radical scavenging activities from Callistemon lanceolatus

Ju Hee Kim1, Jong Chul Byun1, Anil Kumar Reddy Bandi1, Chang-Gu Hyun2and Nam Ho Lee1*
Ju Hee Kim1, Jong Chul Byun1, Anil Kumar Reddy Bandi1, Chang-Gu Hyun2and Nam Ho Lee1*
Email: [email protected]

  •  Accepted: 07 September 2009
  •  Published: 30 November 2009

Abstract

Bioassay-guided investigation of the stems of Callistemon lanceolatus led to the isolation of five compounds such as betulinic acid (1), pyracrenic acid (2), arjunolic acid (3), catechin (4), and piceatannol (5). Their structures were elucidated on the basis of spectral studies as well as by comparison with literature data. Elastase inhibition and DPPH radical scavenging activities wereinvestigated for the isolated compounds. Among these, pyracrenic acid (2) was identified as a potent elastase inhibitor with an IC50 value of 1.5 mg/mL, more active than the control compound, oleanolic acid (IC50 = 3.0 mg/mL). With regard to antioxidative studies, strong to moderate DPPH radical scavenging activities were observed with pyracrenic acid (2), catechin (4) and piceatanol (5).

 

Key words: Callistemon lanceolatus, elastase inhibition, radical scavenging, triterpenoids.