Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Anti-inflammatory property and redox profile of the leaves extract from Morinda citrifolia L.

Mairim Russo Serafini*
  • Mairim Russo Serafini*
  • Departamento de Farmacia, Universidade Federal de Sergipe, Sao Cristovao, Sergipe, Brazil.
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Emiliano de Oliveira Barreto
  • Emiliano de Oliveira Barreto
  • Laboratorio de Biologia Celular, Instituto de Ciencias Biologicas e da Saude, Universidade Federal de Alagoas, Maceio, Alagoas, Brazil.
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Fabiola de Almeida Brito
  • Fabiola de Almeida Brito
  • Laboratorio de Biologia Celular, Instituto de Ciencias Biologicas e da Saude, Universidade Federal de Alagoas, Maceio, Alagoas, Brazil.
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Joao Paulo Almeida dos Santos
  • Joao Paulo Almeida dos Santos
  • Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
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Bruno dos Santos Lima
  • Bruno dos Santos Lima
  • Departamento de Farmacia, Universidade Federal de Sergipe, Sao Cristovao, Sergipe, Brazil.
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Cristiani Isabel Bandero Walker
  • Cristiani Isabel Bandero Walker
  • Departamento de Farmacia, Universidade Federal de Sergipe, Sao Cristovao, Sergipe, Brazil.
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Francilene Amaral da Silva
  • Francilene Amaral da Silva
  • Departamento de Farmacia, Universidade Federal de Sergipe, Sao Cristovao, Sergipe, Brazil.
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Lucindo Jose Quintans-Junior
  • Lucindo Jose Quintans-Junior
  • Departamento de Farmacia, Universidade Federal de Sergipe, Sao Cristovao, Sergipe, Brazil.
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Daniel Pens Gelain
  • Daniel Pens Gelain
  • Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
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Adriano Antunes de Souza Araujo
  • Adriano Antunes de Souza Araujo
  • Departamento de Farmacia, Universidade Federal de Sergipe, Sao Cristovao, Sergipe, Brazil.
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  •  Received: 05 May 2015
  •  Accepted: 22 June 2015
  •  Published: 25 June 2015

Abstract

Morinda citrifolia Linn (Rubiaceae), popularly known as noni, is widely used in folk medicine in the form of decoction and infusion, particularly as anti-inflammatory, depurative, anti-rheumatic and antiulcer remedy. The infusion of M. citrifolia L. leaves is used in popular medicine in Northeast of Brazil to treat inflammatory and painful diseases. The present study was designed to evaluate the antioxidant potential and the anti-inflammatory effect of the aqueous extract from the dried leaves from M. citrifolia L. (EAMC). The free radical scavenging activities were determined for different concentrations using in vitro models, and the inflammatory processes were evaluated by carrageenan-induced pleurisy. The study results indicated a significant dose-dependent antioxidant effect by noni extract as evaluated by total antioxidant potential (TRAP) and total antioxidant reactivity (TAR) assays. Noni extracts also exhibited modest catalase-like activity, and was able to inhibit the levels of proinflammatory cytokines. All experimental data indicate that the EAMC have not only remarkable antioxidant properties but also potential anti-inflamatory properties.

Key words: Morinda citrifolia, antioxidant, inflammation.

Abbreviation

Morinda citrifolia Linn (Rubiaceae), popularly known as noni, is widely used in folk medicine in the form of decoction and infusion, particularly as anti-inflammatory, depurative, anti-rheumatic and antiulcer remedy. The infusion of M. citrifolia L. leaves is used in popular medicine in Northeast of Brazil to treat inflammatory and painful diseases. The present study was designed to evaluate the antioxidant potential and the anti-inflammatory effect of the aqueous extract from the dried leaves from M. citrifolia L. (EAMC). The free radical scavenging activities were determined for different concentrations using in vitro models, and the inflammatory processes were evaluated by carrageenan-induced pleurisy. The study results indicated a significant dose-dependent antioxidant effect by noni extract as evaluated by total antioxidant potential (TRAP) and total antioxidant reactivity (TAR) assays. Noni extracts also exhibited modest catalase-like activity, and was able to inhibit the levels of proinflammatory cytokines. All experimental data indicate that the EAMC have not only remarkable antioxidant properties but also potential anti-inflamatory properties.

Key words: Morinda citrifolia, antioxidant, inflammation.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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