Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Anti-leukemic and topoisomerase I inhibitory effect of Mansonone E isolated from Ulmus davidiana

Keyong Ho Lee1, Choa Hyoung Cho2 and Ki - Hyeong Rhee3*
1Korea Prime Pharm Company, Suwon City, 443-270, Korea. 2College of Environmental and Biosciences, Chonbuk National University, Iksan 570-752, Korea. 3College of Industrial Sciences, Kongju National University, Yesan 340-702, Korea.
Email: [email protected]

  •  Accepted: 16 February 2012
  •  Published: 28 June 2012

Abstract

A compound has been isolated from Ulmus davidiana, which has been traditionally used as the folk medicine material in Asia, and was determined to be sesquiterpene ortho-naphthoquionone (Mansonone E) from spectral data such as UV, IR, MS and NMR spectrometry. This compound showed an inhibitory effect against topoisomerase I and anti-tumor activities at various leukemia cell lines, U937, K562, HL60 and THP-1 using hollow fiber assay.

 

Key words: Ulmus davidiana, topoisomerase I, hollow fiber assay, leukemia.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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