Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3833

Full Length Research Paper

Antiedematogenic activity of Petiveria alliacea L. in bothropic poisoning

Marcio Trevisan
  • Marcio Trevisan
  • Postgraduate Program in Environmental Sciences – Ciamb, Federal University of Tocantins, Palmas, TO, Brazil.
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Patricia Siqueira de Melo Rodrigues
  • Patricia Siqueira de Melo Rodrigues
  • Postgraduate Program in Environmental Sciences – Ciamb, Federal University of Tocantins, Palmas, TO, Brazil.
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Antônio Ítalo dos Santos Nunes
  • Antônio Ítalo dos Santos Nunes
  • Postgraduate Program in Agroenergy – PPGA, Federal University of Tocantins, Palmas, TO, Brazil.
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Milena Dos Santos Falcão
  • Milena Dos Santos Falcão
  • Postgraduate Program in Environmental Sciences – Ciamb, Federal University of Tocantins, Palmas, TO, Brazil.
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Hemilly Cirqueira Martins
  • Hemilly Cirqueira Martins
  • Postgraduate Program in Environmental Sciences – Ciamb, Federal University of Tocantins, Palmas, TO, Brazil.
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Elisandra Scapin
  • Elisandra Scapin
  • Postgraduate Program in Environmental Sciences – Ciamb, Federal University of Tocantins, Palmas, TO, Brazil.
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Marcio Galdino Dos Santos
  • Marcio Galdino Dos Santos
  • Postgraduate Program in Environmental Sciences – Ciamb, Federal University of Tocantins, Palmas, TO, Brazil.
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Carla Simone Seibert
  • Carla Simone Seibert
  • Postgraduate Program in Environmental Sciences – Ciamb, Federal University of Tocantins, Palmas, TO, Brazil.
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  •  Received: 25 September 2022
  •  Accepted: 29 December 2022
  •  Published: 31 December 2022

Abstract

The biodiversity of the Brazilian biomes inspires interest in research about the biological activities of the molecules present in the flora. In this line, Petiveria alliacea a common plant species in the savanna of Tocantins, reported in the treatment for snakebites, was studied to analyze the phytochemical profile and evaluate the activity on the edema caused by Bothrops moojeni snake venom. A qualitative phytochemical prospection and a gas chromatography associated with mass spectrometry was performed. Subsequently, it was evaluated whether the extract triggered acute toxicity in Swiss mice (doses of 300 and 2,000 mg/kg), and no toxic effects were observed. Then, the antiedematogenic activity of the extract was performed when administered orally in simulated envenomation with B. moojeni snake venom. The presence of bioactive polyphenolics, flavonoids, tannins, coumarins, terpene, alkaloids and saponins compounds was shown. No toxic effects were observed, and the test extract showed evident antiedematogenic activity. It is understood that the inhibition of edema induced by the venom was obtained by reducing the pathways of the inflammatory cascade. Therefore, the traditional effect associated with the plant has scientific basis, in the same way, that its constituents were qualified and showed no toxic effects and has antiedematogenic activity.

Key words: Petiveria alliacea, Bothrops moojeni, edema, inflammation, snakebite.