Abstract

In search for plant-derived anticancer compound, it was found that the chloroformextracts obtained from the whole plant of Carpesium rosulatum MlQ. (Compositae) exhibited significant anticancer activity against human tumor cell line, A549, SK-OV-3, SK-MEL-2, XF-498, HCT-15. The structures and stereochemistry of these compounds were established on the basis of analysis of spectra including mp, [α]_D²⁵, IR, UV, EI-MS, MS, ¹H-NMR, ¹³C-NMR and some chemical transformations as follows: 1 (4β,10α-dihydroxy-guaia-8α,12-olide), 2 (4β,10α-dihydroxy-1(2),11(13)-guaiadien-8α,12-olide), 3 (3β,8β-dihydroxy-1α,5α-guaian-10(14)-ene-6α,12-olide). Anticancer activity of compounds obtained from C. rosulatum MIQ. on five tumor cells line was evaluated by procedure of SRB methods. 2 significantly effects to the five human tumor cell lines.

Key words: Carpesium rosulatum, anticancer activity, human tumor cell lines, SRB