Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3830

Full Length Research Paper

In vitro screening of five Hainan plants of Polyalthia (Annonaceae) against human cancer cell lines with MTT assay

Yuan Yuan1,2, Guo-jun Huang2, Tian-shan Wang1 and Guang-ying Chen1*
1Key Lab of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, P. R. China. 2Pharmaceutical College, Chengdu University of TCM, Chengdu 611137, P. R. China.
Email: [email protected]

  •  Accepted: 29 December 2010
  •  Published: 04 March 2011

Abstract

To screen the anticancer potential of the extracts of five Hainan plants of Polyalthia, which are also China Li minority ethnic medicines. The ethanol roots extracts of Polyalthia laui andPolyalthia rumphii inhibited proliferation of the selected four tumor cell lines at dose of 20 and 200 μg/ml demonstrating potential antitumor activities. Furthermore, the chloroform fraction and petroleum ether fractions of P. rumphii and P. laui exhibited cytotoxic effects against the four tumor cell lines and the IC50 values ranged from 0.98 ± 0.3 μg/ml to 58.0 ± 3.5 μg/ml.

 

Key words: Polyalthia, anticancer activity, cell lines, extracts.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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