Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3793

Full Length Research Paper

Biphasic inflammatory effects of Voacanga globosa ethanolic leaf extract in ICR mice

Ruth Marian S. Guzman1*, Reynand Jay C. Canoy1,2,3, Daile Meek C. Salvador1 and Elena S. Catap1,2
1Institute of Biology, College of Science, University of the Philippines, Diliman, Quezon City 1101 Philippines. 2Natural Sciences Research Institute, University of the Philippines, Diliman, Quezon City 1101 Philippines. 3Institute of Human Genetics, National Institutes of Health, University of the Philippines, Manila 1000 Philippines.
Email: [email protected]

  •  Accepted: 23 September 2013
  •  Published: 10 October 2013


Voacanga globosa is an endemic plant traditionally used as remedy for boils in the Philippines. Four concentrations of the ethanolic leaf extracts (0.5, 5, 50 and 100 mg/kg bw) were administered intraperitoneally to 6 to 8 weeks old female imprinting control region (ICR) mice. Mice treated with 5 mg/kg bw V. globosa extract significantly potentiated the inflammatory response, exhibiting the highest edema index and enhanced leukocyte infiltration and hypertrophy. Inflammatory response was reduced at higher concentrations, suggesting that V. globosa might be immunosuppressive at high concentrations. These indicate that the ethanolic leaf extract of V. globosa exhibit biphasic inflammatory effects since it appears immunostimulatory at low concentration and immunosuppressive at high concentrations.


Key words: Voacanga globosa, delayed-type hypersensitivity test, biphasic response, immunomodulation, histopathology, ICR mice.