Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3834

Full Length Research Paper

Reduces cholesterol induced atherosclerotic lesions in aorta artery in hypercholesterolemic rabbits

Mahbubeh Setorki1*, Sedighe Asgary2, Shaghayegh Haghjooyjavanmard 3 and  Bahar Nazari 4 
1Department of Biology,  Izeh Branch , Islamic Azad University,  Izeh,Iran. 2Isfahan Cardiovascular Research Center, Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. 3Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. 4Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Email: [email protected]

  •  Accepted: 17 May 2010
  •  Published: 04 May 2011

Abstract

Atherosclerosis is the leading cause of death in developed countries with many proved risk factors. Vinegar has been proved to have some medical uses and some potential protective effects on atherosclerosis. In this study, effects of vinegar on various risk factors of atherosclerosis and development of atherosclerosis in hypercholesterolemic rabbit have investigated. Rabbits were assigned to four groups and each group received one of experimental diets: normal diet, high cholesterol diet (1% cholesterol), 1% cholesterol supplemented with 5 ml vinegar and 1% cholesterol supplemented with 10 ml vinegar for 8 weeks. Blood samples were collected before and after 8 weeks of experimental diets for measurement of serum C-reactive protein (CRP), nitrite, nitrate, apolipoprotein A (ApoA1) andapolipoprotein B (ApoB100), total cholesterol (TC), fibrinogen and factor VII. At the end of study, fatty streak formation in aorta was determined in all groups. Using vinegar (5 and 10 ml) with hypercholesterolemic diet caused significant reduction in CRP, fibrinogen, factor VII, ApoB100, ApoB/ApoA ratio, TC levels, atherosclerotic lesions in aorta and increased nitrite and nitrate in comparison with hypercholesterolemic diet. Vinegar did not significantly change ApoA1 level compared to high cholesterol diet. These results suggest that vinegar reduced atherosclerosis processes in high cholesterol diet fed animals. More studies are needed to find the exact mechanisms of action.

 

Key words: Vinegar, atherosclerosis, risk factor, fatty streak, C-reactive protein.