Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

The role of hepatoprotective effect of a flavonoid-rich extract of Salvia plebeia R.Br. on carbon tetrachloride-induced acute hepatic injury in mice

Xiao-feng Jin1+, Jie Qian2+ and Yan-hua Lu1*
1State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, PR, China. 2School of Life Sciences and Technology, TongJi University, Shanghai, PR, China.
Email: [email protected]

  •  Accepted: 13 July 2010
  •  Published: 04 May 2011

Abstract

Salvia plebeia R.Br. is a widely distributed grass, which has been used as a folk medicine for the treatment of hepatitis. In this study, a simple method for preparative separation of the flavonoid-rich extract of S. plebeia was established with macroporous resins, the method can be referenced for large-scale enrichment of flavonoid-rich extract from herbal raw materials. The major constituents of FESP, including luteolin-7-glucoside, nepetin-7-glucoside, homoplantaginin, luteolin, nepetin, and hispidulin were determined by HPLC-DAD analysis. The hepatoprotective effect of FESP was evaluated in carbon tetrachloride (CCl4)-induced liver injury in mice. The biochemical results were supplemented by histopathological examination.

 

Key words: Hepatoprotective activity, Salvia plebeia R. Brown (Lamiaceae), flavonoids, histopathological.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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