Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3672

Full Length Research Paper

Medicinal value of Aptosimum albomarginatum (Marloth and Engl.), Albizia anthelmintica (A. Rich Brongn.) and Dicoma schinzii (O. Hoffm.) to a small community living at Gochas, southern Namibia

Sunette Walter
  • Sunette Walter
  • Department of Biological Sciences, Faculty of Science, University of Namibia, Windhoek, Namibia.
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Mervyn Beukes
  • Mervyn Beukes
  • Department of Biochemistry, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria, South Africa.
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Davis Mumbengegwi
  • Davis Mumbengegwi
  • Multidisciplinary Research Centre, University of Namibia, Windhoek, Namibia.
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Ronnie Böck
  • Ronnie Böck
  • Department of Biological Sciences, Faculty of Science, University of Namibia, Windhoek, Namibia.
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  •  Received: 23 October 2017
  •  Accepted: 17 November 2017
  •  Published: 10 December 2017

Abstract

Traditional medicine is widely used, but its effectiveness is often questioned. Biofilm-producing bacteria and fungi are important in difficult-to-treat persistent and recurrent infections. The present study investigated the anti-biofilm properties of crude methanolic extracts from three medicinal plants used in Namibia, namely Aptosimum albomarginatum (Marloth and Engl.), Albizia anthelmintica (A. Rich Brongn.) and Dicoma schinzii (O. Hoffm.). Biofilm formation, inhibition and eradication were determined using microtiter plate assay. Extracts were tested against Escherichia coli ATCC 700928, Staphylococcus aureus ATCC 12600, S. aureus U3300, Bacillus subtilis ATCC 13933, Streptococcus mutans ATCC 25175, Streptococcus sanguinis ATCC 10556, Pseudomonas aeruginosa and Candida albicans. All isolates were strong biofilm producers. A. albomarginatum root extract moderately inhibited biofilm formation in S. mutans ATCC 25175 (60.0%), E. coli ATCC 700928 (51.6%) and P. aeruginosa (49.1%). A. anthelmintica twigs caused 58.4% biofilm inhibition in C. albicans and eradicated S. aureus U3300 biofilm by 74.8%.  D. schinzii leaf extract inhibited P. aeruginosa biofilm by 67.3%, and in addition broke down S. mutans ATCC 25175 biofilm by 44.2%.  These results validate the usefulness of the three plants as traditional medicine in some instances.

Key words: Aptosimum albomarginatum, Albizia anthelmintica, Dicoma schinzii, traditional medicine, anti-biofilm activity, flavonoids, saponins.