Abstract

In an attempt to explore, the hepatoprotective, nephroprotective and anti-malarial effects of some plants growing in Egypt, different parts of Bauhinia purpurae and Tipuana speciosafamily Fabaceae were selected for the current study. Liver and kidney injury were induced in Wistar albino rats using paracetamol. The biochemical parameters such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and total bilirubin were estimated as reflections of the liver condition. Measured kidney parameters were; serum creatinine, serum urea, sodium and potassium level. Liver and kidney samples of rats treated with extracts showed marked improvement in the biochemical parameters were subjected to histopathological study. All the results were compared with the reference drug silymarin. The anti-malarial activity was evaluated in vivousing Plasmodium berghei Infected mice and chloroquine phosphate as positive control. The tested extracts were used in three dose levels and activity was expressed as reduction in blood parasitemia and increase in the mouse survival time. The ethanol extract of B. purpurea flowers (BPFE) was effective in the three used assays. T. speciosa leaves extract (TSLE) showed good nephroprotective and anti-malarial activities.

Key words: Hepatoprotection, nephroprotection, anti-malarial, Bauhinia purpurae, Tipuana speciosa, paracetamol, albino rats.