Paraquat (PQ), as a non-selective herbicide, has been used worldwide for weed control in agriculture. However, some medicine plant would be also weeded in this process. Thereby, herbicide antidote is advocated. In this study, we performed two pathway analysis methods, namely, component-based approaches and protein-protein interaction (PPI)-based approach, to identify more significant pathways associated with PQ application. The results showed that eight pathways were identified in component-based analysis, but twenty-two pathways were in PPI-based approach. Among them, phenylalanine metabolism and ribosome pathways were significant in two analysis methods. We anticipate that more PQ antidote would be developed based on our analysis.
Key words: Paraquat, significant pathway enrichment, Arabidopsis thaliana.
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