Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Combined effects of testosterone propionate and Leptadenia hastata Pers. (Decne) aqueous extracts on immature castrated male rats

Bayala B.1*, Téléfo P. B.2, Savadogo A.3, Sawadogo L.1 and Malpaux B.4
1Laboratory of Animal Physiology, Training and Research Unit in Life and Earth Sciences, University of Ouagadougou, 03 BP 7021 Ouagadougou 03, Burkina Faso. 2Department of Biochemistry, Faculty of Science, University of Dschang, P. O. Box 67, Dschang, Cameroon. 3Laboratoire de Microbiologie et de Biotechnologie, Département de Biochimie-Microbiologie (DBM), Centre de Recherche en Sciences Biologiques, Alimentaires et Nutritionnelles (CRSBAN), University of Ouagadougou,  Ouagadougou, Burkina Faso. 4Reproduction Physiology and Behaviours Section, National Institute for Agronomic Research. (INRA/PRC), 37380 Nouzilly Tours, France.
Email: [email protected]

  •  Accepted: 09 June 2011
  •  Published: 23 April 2012

Abstract

To evaluate the competition between testosterone propionate (TP) and Leptadenia hastataaqueous extracts, immature castrated male Wistar rats were divided into two groups. L. hastata aqueous extracts reduced significantly the weight of androgen-dependant sex glands, the level of phosphatase acid prostatic (PAP) and fructose in seminal vesicles and prostate, and the serum testosterone level. When TP was administered simultaneously with 100, 200 and 400 mg/kg of L. hastata aqueous extracts, a potentiate action was observed with 100 mg/kg of L. hastata by the increase of androgen-dependant sex glands weights, fructose and PAP levels in seminal vesicles and prostate, and the serum testosterone level. The anti-androgenic effect of L. hastata appeared with the doses of 200 and 400 mg/kg which reduced significantly the weight of androgen-dependant sex glands, fructose and PAP levels in seminal vesicles and prostate and serum testosterone level. From these findings, it was concluded that the effect of TP was potentiated with low doses of L. hastata and antagonized with high doses. This study confirmed the anti-androgenic effects of L. hastata aqueous extracts in immature castrated male rats.

 

Key words: Leptadenia hastata, testosterone propionate, anti-androgenic activity, rats.

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