Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3834

Full Length Research Paper

Antifungal activity of the aqueous extract of Stachytarpheta cayennensis, (Rich.) Vahl. (Verbenaceae), on oral candida species

Sideney Becker Onofre*
  • Sideney Becker Onofre*
  • Center of Exact and Environmental Sciences - Postgraduate Program in Technology and Innovation Management - PPGTI - Universidade Comunitária da Região de Chapecó - UNOCHAPECÓ - Chapecó - Santa Catarina - Brazil.
  • Google Scholar
Zípora Morgana Quinteiro dos Santos
  • Zípora Morgana Quinteiro dos Santos
  • Laboratory of Chemistry and Biochemistry of the Universidade Paranaense - UNIPAR - Francisco Beltrão Campus - Paraná - Brazil.
  • Google Scholar
Francini Yumi Kagimura
  • Francini Yumi Kagimura
  • Department of Biochemistry and Biotechnology - Postgraduate Program in Chemical and Biochemical Processes of the Universidade Tecnológica Federal do Paraná - UTFPR - Pato Branco - Paraná - Brazil.
  • Google Scholar
Shaiana Paula Mattiello
  • Shaiana Paula Mattiello
  • Molecular Biology Laboratory - Postgraduate Program in Cellular and Molecular Biology of the Pontifícia Universidade Católica do Rio Grande do Sul - PUCRS - Porto Alegre - Rio Grande do Sul - Brazil.
  • Google Scholar

  •  Received: 30 October 2014
  •  Accepted: 28 December 2014
  •  Published: 10 January 2015


The objective of this study was to evaluate the antifungal activity of the aqueous extract of the leaves of the "verbena" (gervão roxo) Stachytarpheta cayennensis, (Rich.) Vahl. (Verbenaceae), by determining the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) on different species and strains of the genus Candida. In this study, the species Candida albicans, Candida tropicalis, Candida glabrata, Candida stellatoidea, Candida dubliniensis and Candida krusei were included. Four strains of C. albicans and three of C. tropicalis were used, while for the other species only one strain was tested. These yeasts were used in this study because of their importance and frequency in the oral cavity. The yeasts were subjected to treatments with concentrations of the aqueous extract ranging from 0.09 to 25 mg mL-1. The results indicated, however, that concentrations of less than 12.5 mg mL-1 were insufficient to show a fungistatic or fungicidal effect. The concentration of 12.5 mg mL-1  showed a fungistatic effect on most tested strains and species, C. albicans CαFB-12 and ATCC-44858; C. tropicalis CTFB-22 and CTFB29. The fungicidal effect (MFC) was observed only on the species C. krusei for the concentration of 12.5 mg mL-1. Based on the employed methodology, it is concluded that the aqueous extract of S. cayennensis showed an antifungal, mainly fungistatic, effect on oral Candida species.


Key words: Yeasts, candidiasis, metabolites, Stachytarpheta cayennensis.