Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3672

Full Length Research Paper

Effects of 1.8-cineole (eucalyptol) on the spontaneous contractile activity of smooth muscles fibre

Sagorchev Plamen
  • Sagorchev Plamen
  • Department of Biophysics, Medical University, 15-A V. Aprilov Street, 4000 Plovdiv, Bulgaria.
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Lukanov Julian
  • Lukanov Julian
  • Department of Biophysics, Medical University, 15-A V. Aprilov Street, 4000 Plovdiv, Bulgaria.
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Beer André-Michael*
  • Beer André-Michael*
  • Ruhr University Bochum, Im Vogelsang 5 ? 11, 45527 Hattingen, Germany.
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  •  Received: 19 December 2014
  •  Accepted: 30 March 2015
  •  Published: 10 April 2015

Abstract

Eucalyptus oil is frequently used in phytotherapy. The objective of the present paper was to investigate to what extent 1.8-cineole influences the activity of smooth muscle fibres. The effects of 1.8-cineole on the spontaneous contractile activity were investigated in in vitro experiments with circular smooth muscle fibres of guinea pig stomach. 1.8-cineole was found to have agonistic effects on the a1 and a2 adrenergic receptors. These effects can be registered at low concentrations of up to 3 × 10-7 to 2 × 10-5 M 1.8-cineole. At higher concentrations, the well-known spasmolytic effect appears. At concentrations above 4 × 10-4 M 1.8-cineole, the effect of 10-5 M acetylcholine is 100% suppressed. The results allow for the assumption that, besides the spasmolytic effects investigated to date and owing to its specific effects on the a2 adrenergic receptors of the nerve cells, 1.8-cineole brings about an additional improvement to local blood circulation and alleviates pain.

 

Key words: Smooth muscle fibre, 1.8-cineole (eucalyptol), a1 and a2 adrenergic receptors, papaverine, pain, clonidine.