Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3834

Full Length Research Paper

Effects of borage extract in rat skin wound healing model, histopathological study

Mohammad Reza Farahpour1* and Amir Hossein Mavaddati2
1Department of Veterinary Surgery, Islamic Azad University, Urmia Branch, Urmia-Iran. 2DVM, Department of Veterinary Surgery, Islamic Azad University, Urmia Branch, Urmia-Iran.
Email: [email protected]

  •  Accepted: 23 March 2011
  •  Published: 09 February 2012

Abstract

Nowadays, borage flowers and leaves are used medicinally for wound healing because of plant constituents, gamma-linolenic acid, alpha linolenic acid and delta-6-fatty acid. The aim of of the present study was to evaluate the ability of borage extract ointment wound healing process. Under surgical anaesthesia, excisional wounds were made on back of 30 rats by punching. Rats were divided into 3 groups of borage 1.5% ointment, eucerin-vaseline, and control. All the rats were treated with topical ointments daily for 21 days. Histopathological examination was performed on the 3rd, 7th, 14th, and 21st days and the wound healing was assessed. The results showed that wound size of the test groups were reduced early as compared to control group. The significant results of histopathological evaluation were obtained with borage, when compared to the other groups as well as to the control and the placebo. Present study demonstrated that borage extract was capable of promoting wound healing process.
 
Key words: Borage, herbal extract, histopathological study, rat, wound healing.