Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3778

Full Length Research Paper

Influence of quercetin on transforming growth factor b1 in the uterus following Lps-induced abortion in pregnant mice

Qian Yang, Wan-yu Shi and Xiu-hui Zhong*
College of Animal Science and Technology, Agricultural University of Hebei, Baoding, Hebei 071001, China.
Email: [email protected]

  •  Accepted: 28 April 2011
  •  Published: 04 August 2011

Abstract

To investigate the significance of transforming growth factor b1(TGF-b1) in the uterus in early embryo loss (or resorption) and to elucidate the anti-abortive effect and the immunological modulation at the maternal-fetal interaction of quercetin (Que). Lipopolysaccharide (LPS) (0.10 μg/mouse) was injected via the tail vein in order to induce abortion in 7-day-gestation mice which also received quercetin at days 1 to 7 of gestation. Uterine TGF-b1 of each group (n=10) was detected by in situ hybridization. The amount of TGF-b1 in the uterus of LPS-induced abortion mice was much lower (P<0.01) than that of the control mice. When quercetin was used to prevent LPS-induced abortion, more TGF-b1mRNA was counted. The effect of high concentration quercetin on LPS-induced abortion was more significant, and the rate of TGF-b1mRNA was increased to 13.52±0.58, significantly higher than that of LPS-abortion group (P<0.01). The change of TGF-b1mRNA in the mouse’ uterus could be associated with the embryo loss, and quercetin exerts an anti-abortive effect through the modulation of the immune balance at the maternal-fetal interface.

 

Key words: Embryo resorption, transforming growth factor-b1, lipopolysaccharide, quercetin, in situ hybridization.