Abstract

Whole plants of Xanthium brasilicum and Argemone mexicana were extracted by methanol, chloroform and water and then prepared in different concentrations in order to be examined for their trichomonacidal activities in vitro. Their activity was compared with metronidazole using strains of Trichomonas vaginalis freshly isolated from patients. Methanolic extracts of X. brasilicum exhibit 100% inhibition at concentration 500 µg/ml after 192 h, this was compared with metronidazole powder which gave 98.5% inhibition at concentration 312.5 µg/ml at the same time, while the chloroform extracts gave inhibition 100% at 1000 µg/ml after 216 h, mean while, the water extracts gave 100% inhibition at 1000 µg/ml after 192 h. Water extract of A. mexicana gave 100% inhibition 1000 µg/ml after 192 h, while the chloroform and methanol extracts 1000 µg/ml gave 100% inhibition after 216 and 192 h respectively. These studies conducted for both X. brasilicum and A. mexicana they were proved to be potent activities against T. vaginalis.

Key word: Trichomonas vaginalis, Xanthium brasilicum, Argemone Mexican,antitrichomonal activity.