Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3727

Full Length Research Paper

Chambá (Justicia pectoralis) syrup for the treatment of cough and respiratory symptoms: A randomized clinical trial

Wilcare de Medeiros Cordeiro Nascimento
  • Wilcare de Medeiros Cordeiro Nascimento
  • Department of Research and Postgraduation, Faculty of Pharmaceutical Sciences, Federal University of Ceará, Brazil.
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Francisco Plácido Nogueira Arcanjo
  • Francisco Plácido Nogueira Arcanjo
  • Department of Postgraduation in Health Sciences, Faculty of Medicine, Federal University of Ceará, Brazil.
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Mary Anne Medeiros Bandeira
  • Mary Anne Medeiros Bandeira
  • Department of Research and Postgraduation, Faculty of Pharmaceutical Sciences, Federal University of Ceará, Brazil.
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Bruna Linhares Prado
  • Bruna Linhares Prado
  • Department of Postgraduation in Health Sciences, Faculty of Medicine, Federal University of Ceará, Brazil.
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Maria Ester Frota Fernandes
  • Maria Ester Frota Fernandes
  • Department of Research and Postgraduation, Faculty of Pharmaceutical Sciences, Federal University of Ceará, Brazil.
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Elayne Cristina Oliveira Brito
  • Elayne Cristina Oliveira Brito
  • Department of Health Sciences, Faculty of Pharmacy, Centro Universitário INTA, Brazil.
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Bianca Frota Monte
  • Bianca Frota Monte
  • Department of Health Sciences, Faculty of Pharmacy, Centro Universitário INTA, Brazil.
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Aristides Avilo do Nascimento
  • Aristides Avilo do Nascimento
  • Department of Health Sciences, Faculty of Pharmacy, Centro Universitário INTA, Brazil.
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Antonio Flávio Queiroz de Oliveira
  • Antonio Flávio Queiroz de Oliveira
  • Department of Postgraduation in Health Sciences, Faculty of Medicine, Federal University of Ceará, Brazil.
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Leandro Cordeiro Portela
  • Leandro Cordeiro Portela
  • Department of Postgraduation in Health Sciences, Faculty of Medicine, Federal University of Ceará, Brazil.
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Cecília Costa Arcanjo
  • Cecília Costa Arcanjo
  • Department of Postgraduation in Health Sciences, Faculty of Medicine, Federal University of Ceará, Brazil.
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  •  Received: 24 September 2020
  •  Accepted: 22 February 2021
  •  Published: 31 March 2021

Abstract

Cough is a common pediatric complaint, resulting in frequent doctor’s office or hospital visits. In Brazil, the leaves of chambá (Justicia pectoralis) have been used extensively in herbal preparations for the treatment of many respiratory problems such as cough, bronchitis, and asthma. Thus, this study aimed to assess the effectiveness of chambá syrup for the treatment of cough and respiratory symptoms in children. Between November 2017 and February 2018, patients aged 1 to 12 years with respiratory symptoms and cough, and onset of symptoms greater than 48 h were enrolled in this trial. Participants were randomized to receive either chambá syrup in three daily doses or placebo. Effectiveness was assessed through a questionnaire, to measure the intensity of cough and respiratory symptoms, before the intervention and 48 h after, using Likert scale responses. A total of 114 children, 56 in the chambá group and 58 in the placebo group, participated in the study. After 48 h, there was a significant reduction in frequency of cough, severity of cough, severity of nasal congestion, and in improvement in the ability to sleep for both the child and caregiver in the chambá group (p< .0001 for all variables); for participants in the placebo group, there were no significant differences after intervention, in comparison with baseline. In this study population, chambá syrup was effective in the treatment of cough and respiratory symptoms, providing an overall improvement of symptoms when compared to placebo, as well as improving the ability to sleep.

Key words: Cough, clinical trial, pediatrics, Justicia pectoralis.