Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Screening of aerial parts of Abutilon bidentatum for hepatoprotective activity in rabbits

Sammia Yasmin1*, Muhammad Akram Kashmiri2 and Kalsoom Anwar3
1School of Science and Technology, University of Management and Technology, Lahore, Pakistan. 2Chairman, Board of Intermediate and Secondary Education, Lahore, Pakistan. 3Center for Plant Product Research, Department of Chemistry, GC University, Lahore, Pakistan.
Email: [email protected]

  •  Accepted: 30 August 2010
  •  Published: 04 February 2011

Abstract

The objective of this investigation was to study the hepatoprotective activity of aqueous methanolic extracts of aerial parts of Abutilon bidentatum on carbon tetra chloride (CCl4) and paracetamol induced liver damage in rabbits. The extracts at different dosages, administered orally for three days, significantly decrease serum enzymes; Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate (SGOT), Alkaline Phosphate (ALKP), and direct bilirubin. Silymarin was used as a standard hepatoprotective agent. The biochemical observations were supplemented with histopathological examination of rabbit liver sections. The results of this study strongly indicated that aerial parts of A. bidentatum had potent hepatoprotective action against CCl4and paracetamol induced hepatic damage in rabbits. These findings revealed A.bidentatum an indigenous plant to be a potentially valuable herb for liver diseases.

 

Key words: Abutilon bidentatum, hepatoprotective activity, histopathology, paracetamol, CCl4, silymarin.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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