Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3834

Full Length Research Paper

Efficacy and safety of Ziabites (an Iranian traditional medicine compound) on glycemic control in type 2 diabetic patients

Majid Asghari1, Mohsen Naseri1*, Zari Sabet1, Ali Davati2, Mohammad Kamalinejad3, Mohammad Reza Jalali-Nadoushan4, Akbar Shaali5, Sasan Doost5 and Masoud Alamshekan5
1Traditional Medicine Clinical Trial Research Center, Shahed University, P. O. Box 14179-53836, Tehran, Iran. 2Department of Social Medicine, School of Medicine, Shahed University, P. O. Box 14179-53836, Tehran, Iran. 3Department of Internal medicine, Shahid Mostafa Khomeini Hospital, Shahed University, P. O. Box 14179-53836, Tehran, Iran. 4Department of Pathology, School of Medicine, Shahed University, P. O. Box 14179-53836, Tehran, Iran. 5Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, P. O. Box 14179-53836, Tehran, Iran.
Email: [email protected]

  •  Accepted: 10 December 2012
  •  Published: 10 June 2013


This study was designed to evaluate the efficacy and safety of Ziabites on glycemic control in type 2 diabetic patients. The samples consisted of 31 subjects and the doses of Ziabites were equally administered orally in the form of capsule before the breakfast, lunch and dinner. The doses were given for 4 weeks. Ziabites capsule contains Portulaca oleracea L.Rhus coriaria L. and Punica granatum L. The efficacy was assessed on the basis of the following parameters: fasting blood glucose (FBG), 2 h postprandial plasma glucose (2hppG), serum fructosamine, triglyceride (TG) and total cholesterol (Tc) levels. Also, side effects were assessed by history and physical and biochemical examinations. All of the assays were performed on the starting day of study and after 4 weeks. After 4 weeks of treatment with Ziabites capsule, there was a significant decrease (P<0.05) in mean FBG and 2hppG levels when compared with its levels on starting day. Data of mean serum fructosamine levels, showed no significant different between the starting day and after 4 weeks. Also, the reductions of mean serum TG and Tc levels after treatment, were not significant (P>0.05). This study indicated that Ziabites capsule is effective in decreasing fasting and postprandial plasma glucose levels among type 2 diabetic patients without any side effects.


Key words: Ziabites, Portulaca oleracea L., Rhus coriaria L., Punica granatum L., diabetes mellitus.