Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3834

Full Length Research Paper

Antiviral activity of leaves extracts of Marrubium alysson L.

Edziri H.1*, Mastouri M.2, Mahjoub M. A.3, Ammar S.3, Mighri Z.3, Gutmann L.4 and Aouni M.1  
1Laboratory of Communicable Diseases and Biologically Active Substances, Faculty of Pharmacy-5000-Monastir-Tunisia. 2Laboratoire de Microbiology CHU FattoumBouguiba -5000 - Monastir, Tunisia. 3Laboratory of Chemistry of Natural and Synthetic Organic 99/UR/12-26, Faculty of Monastir, 5000 Monastir, Tunisia. 4Laboratory of Microbiology and Virology, Hôpital Européen George Pompidou, APHP, 20 Rue Leblanc 75905 Paris Cedex 15, France.  
Email: [email protected]

  •  Accepted: 23 September 2010
  •  Published: 04 February 2011

Abstract

Petroleum ether, ethyl acetate, chloroform, butanol and methanol extracts of the leaves ofMarrubium alysson L. were screened for in vitro antiviral activity against human cytomegalovirus (HCMV) strain AD-169 (ATCC Ref. VR 538) and coxsackie B virus type 3 (CoxB-3) using a cytopathic effect (CPE) reduction assay. Total phenolic content of the extracts were determined by the Folin-Ciocalteu colorimetric method. The most potent inhibition was observed with methanol extract, which inhibited HCMV and Cox B3 viruses replication at 100 µg/ml without showing cytotoxic effects. Good activities were also found with the ethyl acetate, butanol and chloroform extracts which exhibited antiviral effect against both HCMV and Cox B3 at 100 to 250 µg/ml.

 

Key words: Marrubium alysson L., antiviral activity, total phenolic content.

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