Full Length Research Paper
Abstract
Xuebijing injection (XBJ) is one of Chinese materia medica standardized products which was extracted from Salvia miltiorrhiza Bge, Carthamus tinctorius L, Paeonia lactiflora Pall,Ligusticum chuanxiong Hort. and Angelica sinensis, has the actions of activating blood circulation and clear the meridians to melt away toxin factor. Our aim was to observe whether or not XBJ have neuroprotective effects on the patients with traumatic intracranial hematoma (TICH). If so, we would explain the mechanism involved. Forty patients with TICH were randomly assigned to trial group and a control group (20 patients per group). Routine medication was given to the patients of the two groups, and XBJ was administered intravenously to patients in the trial group additionally. The scores of GCS was recorded pre and post-treatment of the two groups, along with GOS after therapy. We also measured each patient’ volume of the intracranial hematoma and coagulation indexes pre- and post-treatment. In addition, the activities of antioxidative enzymes were also evaluated in the study. XBJ could promoteglasgow coma scale (GCS) and glasgow outcome scale (GOS) after therapy for the trial group compared with the control group (p<0.01). There was a signiï¬cant post-treatment difference in the intracranial hematoma absorption between the two groups (p<0.01). The plasma levels of ï¬brinogen and D-dimer in the trial group were signiï¬cantly decreased after therapy (p<0.01). XBJ also could decrease the serum level of malondialdehyde (MDA), increased the activities of superoxide dismutase (SOD), catalase (CAT) and the serum level of glutathione (GSH). These results suggest that XBJ exerts signiï¬cant neuroprotective effects to the recovery of patients with TICH safely, which may be likely through the coagulation improvement and antioxidation and antilipid peroxidative properties of its action.
Key words: Xuebijing injection, traumatic intracranial hematoma, clinical study, coagulation, function, oxidative stress.
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