Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Citotoxic activity of isoflavan-cinnamylphenols from Dalbergia congestiflora on HeLa cells

Rosa Martha Perez Gutierrez1* and Efren Garcia Baez2
1Laboratorio de Investigacion de Productos Naturales, Escuela Superior de Ingeniería Química e Industrias Extractivas, IPN. Av. Instituto Politecnico Nacional S/N Unidad Profesional Adolfo Lopez Mateos, Col. Zacatenco, 07758, D.F., Mexico. 2Departamento de  Biotecnologia, UPIBI-IPN, Col. San Pedro Zacatenco, Mexico D.F., CP 07360. 
Email: [email protected]

  •  Accepted: 28 September 2013
  •  Published: 25 October 2013

Abstract

A systematic molecular fragmentation pathway (SMFP) was designed as an identifier to detect isoflavan-cinnamylphenols in methanol extract of Dalbergia congestiflora. Comprehensive mass spectral fragmentation patterns for extract of D. congestiflora were established using high-performance liquid chromatography (HPLC)/mass spectrometry (MS) equipment. Seven (1 to 7) tautomeric forms of isoflavan-cinnamylphenols (IFCPs) were identified by electron ionization mass spectroscopy (ESI-MS). These compounds were cytotoxic to the HeLa cervical cancer cell line. Compounds 1, 2 and 3 showed significant activity against HeLa cancer cell line in vitro with IC50 values in the range 1.70 to 3.34 µg/ml. Compounds 4 to 7 showed moderate cytotoxicity with IC50 values ranging from 2.23 to 8.67 µg/ml.

Key words: Dalbergia congestiflora, isoflavan-cinnamylphenols, tautomeric form, mass spectrometry.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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