Abstract

The anti-aggregatory property of platelets by many plant extracts and natural products are being explored as cardioprotective drugs because of their relative effectiveness, limited side effects, and low cost. Current study has been designed to evaluate platelet aggregation inhibition potential of bark of Acacia leucophloea, a traditional medicinal plant used by indigenous communities of Pakistan for this purpose. A. leucophloea bark crude methanolic extract (Al. Cr) exhibited potent platelet aggregation inhibitory activity and dose-dependent inhibition was observed against adenosine 5’ diphosphate (ADP)-induced human platelet aggregation with concentration range (0.3 to 3.00 mg/ml). This preliminary screening suggests that Al. Cr may be taken as a candidate for isolation of natural compounds with beneficial effects on aberrant platelet activation mediated cardiovascular disorders.

Key words: Platelet aggregation inhibition, Acacia leucophloea, Pakistan.