Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3806

Full Length Research Paper

Anti-aging activity of Korean pine (Pinus koraiensis) leaf extracts demonstrated through the induction of mitochondrial biogenesis in mice

Mi-Young Lee1*, Hyojun Kim1, Sungwook Chae1, Md Romij Uddin1,2, Hye-Won Lee1, Goya Choi3, Young Hwa Kim1, A-Rang Im1 and Bong Ju Kang4
1KM-Based Herbal Drug Research Group, Korea Institute of Oriental Medicine, Daejeon, 305-811, South Korea. 2Department of Crop Science, Chungnam National University, Daejeon 305-764, South Korea. 3Herbal Medicine Resources Group, Korea Institute of Oriental Medicine, Daejeon, 305-811, South Korea. 4Infrastructure Management Team, Korea Institute of Oriental Medicine, Daejeon, 305-811, South Korea.  
Email: [email protected]

  •  Accepted: 20 May 2013
  •  Published: 03 July 2013

Abstract

Age-related increases in cellular damage and death have been associated with oxidative stress. Mitochondrial biogenesis is likely to be involved in the regulation of cell metabolism and signal transduction. In addition, there is a growing body of evidence suggesting that mitochondrial biogenesis is a key regulator of mitochondrial reactive oxygen species (ROS). Our results demonstrate that Pinus koraiensis leaf (PKL) extract reduces oxidative stress and, at the same time, stimulates the proliferation of mitochondria through a peroxisome proliferation-activated receptor coactivator 1α (PGC-1α) signaling pathway. The effects of PKLs were associated with the induction of genes associated with oxidative phosphorylation and mitochondrial biogenesis pathways, and were largely explained by PKL-mediated decrease in PGC-1α acetylation and an increase in PGC-1α activity. PKL extracts induced a PGC-1α dependent pathway in mitochondria capable of efficient and balanced bioenergetics to reduce oxidative stress and attenuate endogenous oxidative damage.

 

Key words: Pinus koraiensis, mitochondrial biogenesis, reactive oxygen species (ROS), peroxisome proliferation-activated receptor coactivator 1α (PGC-1α).