Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3830

Full Length Research Paper

Compound Danshen dripping pills for stable angina: Meta-analysis of randomized controlled trials

Yafeng Li1, Yanli Wang1, Qi Yu1, Kena Wei1, Meng Li1, Sihai Zhao1, Yuzuru Kurabayashi2, Jianglin Fan3 and Enqi Liu1*
1Research Institute of Atherosclerotic Disease, Xi’an Jiaotong University School of Medicine, Xi'an, 710061, China. 2 Department of Acupuncture, Morinomiya University of Medical Sciences, Osaka 559-0034, Japan. 3Department of Molecular Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, 409-3898, Japan.
Email: [email protected] or [email protected]

  •  Accepted: 01 February 2011
  •  Published: 04 June 2011

Abstract

The aim of this study was to perform a meta-analysis of randomized controlled trials (RCTs) comparing the compound Danshen dripping pill (DSP) with isosorbide dinitrate (ID) in treatment of stable angina. A search of MEDLINE and CNKI (China national knowledge infrastructure) databases was performed to investigate studies published from 1966 to 2010. Trials comparing the use of DSP versus ID in treating stable angina were assessed. Of the 245 studies screened, 15 RCTs including 1536 patients (DSP therapy 847; ID therapy 689) were analyzed. There was evidence that DSP treatment improved symptoms more than ID treatment (93.4% vs. 73.8%, odds ratios (OR) 4.92 points, 95% confidence intervals (CI) 3.36~7.20). DSP as compared to ID treatment also resulted in superiorelectrocardiograms (ECG) improvements (69.7% vs. 46.3%, OR 2.75 points, 95% CI 2.14~3.55). In addition, the results showed that DSP plus routine therapy compared with ID plus routine therapy increased the improvement in symptoms (93.6% vs. 79.2%, OR 4.04 points, 95% CI 2.16~7.56) and ECG results (70.8% vs. 51.3%, OR 2.72 points, 95% CI 1.79~4.12). The study suggested that DSP is an effective therapy option with which to treat stable angina.

 

Key words: Danshen, meta-analysis, angina pectoris.