Full Length Research Paper
Abstract
The octillol-type derivatives 3 and its epimer 4 had been designed and synthesized from 20(S)-panaxadiol. The structures of 3 and 4 were confirmed by ESI-MS, 1H-NMR, 13C-NMR and X-ray diffraction. The crystal data showed the configuration of C-24 of two epimers as R-form (3) and S-form (4, epimer) respectively. Compound 3 was evaluated in vitro for its protective effect on cultured myocardiocytes with anoxia/reoxygen injury and compound 4 had none of this activity.
Key words: Octillol-type derivative, epimer, X-ray diffraction, protective effect, cultured myocardiocytes with anoxia/reoxygen injury.
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