Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Short Communication

Exploration of the anti-diabetic effect of the matured seeds of Dioclea reflexa

Adepoju Adeyinka GK*
  • Adepoju Adeyinka GK*
  • Department of Clinical Pharmacy and Biopharmacy, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu, Ogun State, Nigeria.
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Balogun O.M.
  • Balogun O.M.
  • Department of Clinical Pharmacy and Biopharmacy, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu, Ogun State, Nigeria.
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  •  Received: 21 September 2010
  •  Accepted: 12 August 2011
  •  Published: 10 June 2014

Abstract

The study aimed at exploring the anti-diabetic effect of the seed flour of Dioclea reflexa on alloxan-induced diabetic rats. Thirty Wistar rats of both sexes were exposed to respective doses of the seed flour and the standardized drugs (Gliclazide 6.1 mg/kd body weight and Metformin 60 mg/kg body weight) according to the group specifications.  The seed flour at a dose of 2 g/kg body weight per oral once daily was found to be more effective than any of the standard drugs with which it was compared. The result showed that D. reflexa seed flour possessed potent oral hypoglycaemic property probably mediated via increased peripheral utilization of glucose.

 

Key words: Dioclea reflexa, anti-diabetic, anti-hyperglycaemia, seed flour, hypoglycaemic, glucose utilization, alloxan-induced diabetes.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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