Abstract

Anti-inflammatory activity of chloroform and methanol extracts from aerial parts of Hyptis albida was tested on different pharmacological models in rats and mice. The plant was collected in Guadalcazar San Luis Potosí State, dried and powdered. The extracts were obtained by heating the solvent to its boiling point. The extracts free of solvent were tested in two pharmacological models, carrageenan-induced edema and 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced mouse ear edema. In the case of carrageenan model, the extract was administered orally using polyvinylpyrrolidone (PVP) like vehicle and for the TPA, topical administration was used. Results showed that chloroform and methanol extracts had effects on TPA-induced edema, the major effect was observed with the chloroform extract. Also this extract inhibited edema cause by multiple applications of TPA (53.2%). In carrageenan induced edema test, the chloroform extract showed no dose dependent response at doses of 100, 200, and 400 mg/kg. The results suggest that H. albida could be a source for compounds with anti-inflammatory effect.

Key words: Hyptis albida, anti-inflammatory activity, 12-O-tetradecanoylphorbol 13-acetate (TPA), carragenan