Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Antioxidant and anti-plasmodial activity of extracts from three Ugandan medicinal plants

Torunn Stangeland1*, Helle Wangensteen2, Esther Katuura3, Kare A. Lye1 and Berit S. Paulsen2
1Department of Ecology and Natural Resource Management, Norwegian University of Life Sciences, P. O. Box 5003, NO-1432 Aas, Norway. 2Department of Pharmaceutical Chemistry, School of Pharmacy, Division of Pharmacognocy, University of Oslo, P. O. Box 1068 Blindern, N-0316 Oslo, Norway. 3Department of Pharmacology and Therapeutics, Medical School, Makerere University, P. O. Box 7072, Kampala, Uganda.
Email: [email protected]

  •  Accepted: 18 August 2010
  •  Published: 18 September 2010

Abstract

Extracts from three plants; Hallea rubrostipulata, Vernonia adoensis andZanthoxylum chalybeum, were tested for antioxidant activity using three assays2,2-Diphenyl-1-picrylhydrazyl (DPPH), Ferric Reducing Ability of Plasma (FRAP) and total phenol content) and anti-plasmodial activity using an Enzyme-Linked Immunosorbent Assay (ELISA) on Plasmodium falciparum chloroquine sensitive strain MRA-285 line. The objective of the study was to find candidates for making anti-malarial phytomedicines. The water extract of H. rubrostipulata showed very high anti-plasmodial activity (IC50= 1.95 µg/ml) and high antioxidant activity as well. Thirteen other extracts had high anti-plasmodial activity ranging from 2.14 to 3.63 µg/ml (chloroquine IC50= 8 µg/ml). We found high correlation between the different antioxidant assays.

 

Key words: Hallea rubrostipulata, Vernonia adoensis, Zanthoxylum chalybeum,2,2-Diphenyl-1-picrylhydrazyl, fluorescence recovery after photobleaching, total phenolic compounds

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