Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Isolation, synthesis and pharmacological evaluation of some novel curcumin derivatives as anticancer agents

Dinesh Kumar1*, Pushpesh kumar mishra2, Anita v.k. anand3, Pramod kumar agrawal4and Ranjit mohapatra1
1University Department of Pharmaceutical sciences, Utkal University, Vani Vihar, Bhuvaneswar, Orissa, India. 2Sanjay College of Pharmacy, NH-2, Chaumuhan, Mathura (India). 3Department of Chemistry, St. Johns Degree College, Agra, India. 4Department of Organic Chemistry, Rastriya Inter College, Patalauni, Mathura, India.
Email: [email protected]

  •  Accepted: 16 January 2012
  •  Published: 16 April 2012

Abstract

Microwave assisted a series of novel curcumin analogues that were synthesized by altering β-diketone system with olifinic bond (4 to 12) and evaluated their anticancer activity against KB-oral and mouth, CaCO2-colon, MCF-7-breast, WRL-68 liver, HepG-2-liver human cancer cell lines. The naturally occurring curcuminods (A, B and C) showed excellent IC50ranging from 0.0006 to 6.0 µg/ml. Analogues 5, 7, 10 and 12 showed very good anticancer activity with IC50 value 0.003, 0.0012, 0.33 and 0.067 µg/ml, respectively as compare to curcumin and taxol with IC50 0.044 and 0.001 µg/ml, respectively.

 

Key words: Curcumin, anticancer, curcuminoids, turmeric, natural product and microwave.

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