Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3828

Full Length Research Paper

Purple sweet potato color attenuates D-galactose-induced renal injury in mice by inhibiting the expression of NF-κB-dependent inflammatory genes

Shao-hua Fan1#, Zi-feng Zhang1#, Yan-yan Wang2#, Yuan-lin Zheng1*, Jun Lu1, Dong-mei Wu1, Qun Shan1 and Bin Hu1
1Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, School of Life Science, Xuzhou Normal University, Xuzhou 221116, P.R. China. 2First Renmin Hospital of Xuzhou, Xuzhou 221002, P.R. China.
Email: [email protected], [email protected]

  •  Accepted: 01 February 2012
  •  Published: 09 June 2012

Abstract

This study was carried out to investigate the protective effect of purple sweet potato color (PSPC) against D-galactose (D-gal)-induced renal injury and the possible mechanisms in mice. Histopathological analysis showed PSPC could significantly attenuate renal injury induced by D-gal. We found the protective effect of PSPC against D-gal induced renal injury might be caused, at least in part, by renewing the activity of antioxidant enzymes with a reduction in lipid peroxidation. These results implied that PSPC had a potential antioxidative activity. Furthermore, we found that PSPC had anti-inflammatory effects by reducing the expression of iNOS, COX-2, NF-κB p65, TNF-α, IL-1β, IL-6 and by decreasing the production of NO in D-gal-treated mice. Our findings suggested PSPC could attenuate renal injury induced by D-gal probably through its antioxidant and anti-inflammation properties. This study provided novel insights into the mechanisms of PSPC in the protection of the kidney.

 

Key words: purple sweet potato color, D-galactose, antioxidant enzymes, NF-κB, proinflammatory cytokines.