Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Neuroprotective effect of salidroside on hemisection-induced spinal cord injury in rats

Xinyu Fan1,2, Jun Li1, Yueliang Zhu1, Baochuang Qi3, Liqi Xu1 and Yongqing Xu1*
1Department of Orthopedics, Kuming General Hospital of Chengdu Military Region, Kuming 650032,Yunnan Province, PR China. 2Department of Orthopedics, The Third Military Medical University, Chongqing 400038, PR China. 3Department of Orthopedics, The First General Hospital of Yibin, Yibin 644000, Sichuan Province, PR China.
Email: [email protected]

  •  Accepted: 15 March 2012
  •  Published: 03 June 2013

Abstract

The effect of salidroside on hemisection-induced spinal cord injury (SCI) in rats was investigated. The Sprague Dawley (SD) rats were randomly divided into six groups: Sham control group, SCI model group, the methylprednisolone sodium succinate (MPSS) group, the salidroside-low dosage group, the salidroside-moderate dosage group and the salidroside-high dosage group. The SD rats were hemisected at spinal cord at the T8 vertebra to establish SCI models. 24 h after operation, different dosage of salidroside increased the superoxide anion (O2−) level and superoxide dismutase (SOD) activity, and reduced malondialdehyde (MDA) content. Noticeably, salidroside at the 100 mg/kg dosage exhibited similar effects as MPSS, which has been frequently used for clinical acute SCI. These results suggested that salidroside can significantly suppress oxidation in acute SCI.

 

Key words: Salidroside, spinal cord injury (SCI), oxidation.

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