Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3832

Full Length Research Paper

Prevention of CCl4 induced adrenal oxidative stress in rat by Sonchus asper

Rahmat Ali Khan, Muhammad Rashid Khan*, Sumaira Sahreen, Shumaila Jan, Jasia Bokhari and Umbreen Rashid
Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University Islamabad, Pakistan.
Email: [email protected]

  •  Accepted: 21 June 2011
  •  Published: 04 August 2011


Sonchus arvensis is used as salad, vegetable and as a human diet in Pakistan, traditionally used in the treatment of various ailments. This study was designed to investigate the mathanol extract of S. arvensis was evaluated against CCl4-induced adrenal oxidative stress in rat. The extract was administered to rats after 48 h of CCl4 treatment (3 ml/kg b.w., 30% in olive oil) twice a week for 4 weeks. CCl4 induction in rats caused reduction of antioxidant enzymes (CAT, SOD, GST, GSR, GSH-Px, and QR) while increased lipid peroxidation (TBARS) which are significantly (P<0.01) reversed by mathanol fraction of S. arvensis (CAT, SOD, GST, GSR, GSH-Px, and QR) enzymes. It is inferred that S. arvensisefficiently protects adrenal injuries induced by CCl4 in rats, possibly through antioxidant effects of bioactive compounds present in the fraction.


Key words: Sonchus asper, adrenal gland, antioxidant enzymes, carbon tetrachloride, glutathione reduced (GSH), thiobarbituric acid (TBARS).


CAT, Catalase; SOD, super oxide dismutase; GST, glutathione-S-transferase; GSR, glutathione reductase; GSH-px, glutathione peroxidases; QR, quinone reductase; GSH, glutathione reduced; TBARS, thiobarbituric acid.