Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3582

Full Length Research Paper

Bio-guided anti-cariogenic and phytochemical valorization of Guiera senegalensis and Pseudocedrela kotschyi stem extracts

Guessan Bi Goble Landry
  • Guessan Bi Goble Landry
  • Laboratoire de Chimie Bio-Organique et de Substances Naturelles/UFR-SFA/ Université Nangui Abrogoua, 02 BP 801 Abidjan 02, Côte d’Ivoire.
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Kadja Amani Brice
  • Kadja Amani Brice
  • Laboratoire de Chimie Bio-Organique et de Substances Naturelles/UFR-SFA/ Université Nangui Abrogoua, 02 BP 801 Abidjan 02, Côte d’Ivoire.
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Cottet Kevin
  • Cottet Kevin
  • Université Paris 13, Sorbonne Paris Cité, Laboratoire CSPBAT, CNRS UMR 7244, F-93017 Bobigny Cedex, France.
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Lecouvey Marc
  • Lecouvey Marc
  • Université Paris 13, Sorbonne Paris Cité, Laboratoire CSPBAT, CNRS UMR 7244, F-93017 Bobigny Cedex, France.
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Mamyrbekova-Békro Janat Akhanovna
  • Mamyrbekova-Békro Janat Akhanovna
  • Laboratoire de Chimie Bio-Organique et de Substances Naturelles/UFR-SFA/ Université Nangui Abrogoua, 02 BP 801 Abidjan 02, Côte d’Ivoire.
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Békro Yves-Alain
  • Békro Yves-Alain
  • Laboratoire de Chimie Bio-Organique et de Substances Naturelles/UFR-SFA/ Université Nangui Abrogoua, 02 BP 801 Abidjan 02, Côte d’Ivoire.
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  •  Received: 25 September 2018
  •  Accepted: 12 October 2018
  •  Published: 25 November 2018

Abstract

The objective of the present study is to carry out bio-guided phytochemical investigation of Guiera senegalensis and Pseudocedrela kotschyi stem extracts. The two plants are used as toothpicks for oral hygiene. The inhibition test revealed a bacteriostatic effect of hexane extract PK1 of P. kotschyi against Streptococcus mutans ATCC 25175 and Streptococcus salivarius ATCC 20560, two bacterial cariogenic strains, with a decrease in the number of bacterial colonies of 1 Log/control. The aqueous extract GS5 obtained from the stems of G. senegalensis is bactericidal, with total inhibition of S. salivarius ATCC 20560. The antimicrobial effect of the stem extracts from the two plants studied varies according to the plant species and the type of bacterial strain. The phytocompounds 8-Hydroxy-6,7-dimethoxy-3-methylisochroman-4-one, 1-(4-hydroxy-3-methoxyphe-nyl) propane-1,2-dione and (4E, 15E) -Nonadeca-4,15- dien-10-one were isolated, respectively from GS5A extracts of G. senegalensis and PK1 of P. kotschyi by normal column chromatography.

Key words: Guiera senegalensis, Pseudocedrela kotschyi, stem extracts, Streptococcus mutans, Streptococcus salivarius, spectroscopic characterization.