Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Antifungal activity and synergistic effect of acetophenones isolated from species Croton against dermatophytes and yeasts

Francisca Lidiane Linhares de Aguiar
  • Francisca Lidiane Linhares de Aguiar
  • Graduate Program in Pharmaceutical Sciences, Pharmacy, Odontology and Nursing College, Federal University of Ceará, 6030-160, Fortaleza, Ceará, Brazil.
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Selene Maia de Morais
  • Selene Maia de Morais
  • Department of Chemistry, State University of Ceará, 60740-000, Fortaleza, CE, Brazil.
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Hélcio Silva dos Santos
  • Hélcio Silva dos Santos
  • Department of Chemistry, Science and Technology Center, Vale do Acaraú State University, 62040-370, Sobral, Ceará, Brazil.
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Maria Rose Jane Ribeiro Albuquerque
  • Maria Rose Jane Ribeiro Albuquerque
  • Department of Chemistry, Science and Technology Center, Vale do Acaraú State University, 62040-370, Sobral, Ceará, Brazil.
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Paulo Nogueira Bandeira
  • Paulo Nogueira Bandeira
  • Department of Chemistry, Science and Technology Center, Vale do Acaraú State University, 62040-370, Sobral, Ceará, Brazil.
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Erika Helena Sales de Brito
  • Erika Helena Sales de Brito
  • College of Nursing, International University of African-Brazilian Lusophone Integration, Palmares Campus, Acarape, Ceará, Brazil.
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Marcos Fábio Gadelha Rocha
  • Marcos Fábio Gadelha Rocha
  • Department of Pathology and Legal Medicine, School of Medicine, Specialized Medical Mycology Center, Federal University of Ceará, Fortaleza, Ceará, Brazil.
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Raquel Oliveira dos Santos Fontenelle
  • Raquel Oliveira dos Santos Fontenelle
  • Agricultural and Biological Sciences Center, Vale do Acaraú State University, Sobral, 62040-370, Sobral, Ceará, Brazil.
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  •  Received: 06 January 2016
  •  Accepted: 09 March 2016
  •  Published: 03 May 2016

Abstract

The aim of this study was to evaluate acetophenones isolated from Croton spp. for antifungal activity in vitro against Candida albicans, Microsporum canis and Trichophyton rubrum, and to evaluate the toxicity of these substances in vivo. The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were determined using the broth microdilution method. The combined effect of the 2-hydroxy-3,4,6-trimethoxyacetophenone with ketoconazole was evaluated using the checkerboard technique. The toxicity was determined using Artemia salina L. The compounds were active against T. rubrum, with MICs ranging from 1.25 to 2.5 mg/mL. Similar results were obtained for M. canis, with MICs ranging from 5.0 to 10.0 mg/mL. In the toxicity tests, 2-hydroxy-4,6-dimethoxyacetophenone and 2-hydroxy-3,4,6-trimethoxyacetophenone presented LC50 of 46.22 and 75.55 µg/mL, respectively. 2-hydroxy-3,4,6-trimethoxyacetophenone exhibited a synergistic effect with ketoconazole.

Key words: Checkerboard, Croton spp., fungal infections, Microsporum canis, Trichophyton rubrum.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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