Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3778

Full Length Research Paper

Screening of Acacia modesta for antifungal, anti-termite, nitric oxide free radical scavenging assay and brine shrimp cytotoxic activities

Bashir Ahmad1*, Ibrar khan1, Shumaila Bashir2, Sadiq Azam1 and Niaz Ali3
1Pharma Biotech Lab, Centre of Biotechnology and Microbiology, Pakistan. 2Department of Pharmacy, University of Peshawar, Khyber, PukhtoonKhwa, Pakistan. 3Department of Pharmacy, University of Malakand, Pakistan.
Email: [email protected]

  •  Accepted: 22 March 2011
  •  Published: 04 August 2011

Abstract

A variety of useful bioactive products are produced by the self generating machines, that is, plants. This make us interested in screening the crude methanolic extract and various fractions of Acacia modesta for antifungal, anti-termite, nitric oxide free radical scavenging and brine shrimp cytotoxic activities. The chloroform (CHCl3) fraction exhibited low activity (15%) against Fusarium oxysporum. The crude methanolic extract exhibited good activity against Heterotermes indicola (termite). The CHCl3 fraction showed moderate cytotoxic activity (40%) against brine shrimp. The results of nitric oxide free radical scavenging activity indicate that the crude methanolic extract, n- hexane and ethyl acetate (EtOAc) fractions of A. modesta have concentration dependent free radical scavenging activity.

 

Key words: Acacia modesta, antifungal, anti-termite, nitric oxide free radical scavenging activity, brine shrimp cytotoxic activity.