Investigation was carried out on the effects of 50mg/mL and 100mg/mL concentration of methanol and omidun extracts of root of V. paradoxa on hematological parameters of diarrhea induced albino rats. A total of 5 test organisms ((Shigella dysenteriae, Salmonella typhi, Escherichia coli ATCC 25922,Enteropathogenic Escherichia coli ‘EPEC ATCC 43887’, Enterohemorrhagic Escherichia coli ‘EHEC ATCC 43889’) associated with diarrhea were used in study. Four groups containing 5 rats per group were treated as follows: Group I rats served as the positive control group and were neither infected nor treated. Group II rats served as the negative control group and were only infected with EPEC but not treated and 2 sub groups of group III rats (treated group) were infected with EPEC and treated with 50mg/mL of omidun extract 100mg/mL in each sub group. These steps of treatment were repeated for all the test organisms and methanol extract. Results showed that methanol and omidun extracts of V. paradoxa reduced the number of diarrhea by the treated rats and the number of diarrhea was more reduced with 50mg/mL than 100mg/mL. Also, 100mg/mL concentration of omidun and methanol extracts caused significant (P<0.05) decrease in the values of WBC, RBC and PCV than 50mg/mL. Also, values of WBC and PCV were slightly but not significantly (P>0.05) higher in rats treated with omidun extract than those treated with methanol extracts but value of RBC was higher in rats treated with methanol extracts than in those treated with omidun extract. Administration of root extract of V. paradoxa may be safe at 50mg/mL concentration tested and might pose stress to as well as compromise pathological status of animals Key words: V. paradoxa, control, diarrhea,Pathological, compromise