Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3638

Full Length Research Paper

In vivo antitumor effect of the aqueous extract of Punica granatum in the sarcoma 180 murine model

Talita Santos Bastos
  • Talita Santos Bastos
  • Tiradentes University, 300 Murilo Dantas Ave, Farolândia, 49032-490 Aracaju, SE, Brazil.
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Danilo Barauna Nascimento da Costa
  • Danilo Barauna Nascimento da Costa
  • Tiradentes University, 300 Murilo Dantas Ave, Farolândia, 49032-490 Aracaju, SE, Brazil.
  • Google Scholar
Rafael Barreto Vieira Valois
  • Rafael Barreto Vieira Valois
  • Tiradentes University, 300 Murilo Dantas Ave, Farolândia, 49032-490 Aracaju, SE, Brazil.
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Sara Maria Thomazzi
  • Sara Maria Thomazzi
  • Department of Physiology, Federal University of Sergipe, Marechal Rondon Ave, 49100-000 São Cristóvão, SE, Brazil.
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Marismar Fernandes do Nascimento
  • Marismar Fernandes do Nascimento
  • Tiradentes University, 300 Murilo Dantas Ave, Farolândia, 49032-490 Aracaju, SE, Brazil.
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Grace Anne Azevedo Doria
  • Grace Anne Azevedo Doria
  • Department of Physiology, Federal University of Sergipe, Marechal Rondon Ave, 49100-000 São Cristóvão, SE, Brazil.
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Ricardo Guimaraes Amaral
  • Ricardo Guimaraes Amaral
  • Department of Physiology, Federal University of Sergipe, Marechal Rondon Ave, 49100-000 São Cristóvão, SE, Brazil.
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Silvana Vieira Floresta Gomes
  • Silvana Vieira Floresta Gomes
  • Research and Technology Institute (ITP), 300 Murilo Dantas Ave, 49032-490 Aracaju, SE, Brazil.
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Isabel Bezerra Lima-Verde
  • Isabel Bezerra Lima-Verde
  • Tiradentes University, 300 Murilo Dantas Ave, Farolândia, 49032-490 Aracaju, SE, Brazil.
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Claudia Andrea Lima Cardoso
  • Claudia Andrea Lima Cardoso
  • Course of Chemistry, State University of Mato Grosso do Sul, Rodovia Dourados-Itahum, Km 12, 79804-970 Dourados, MS, Brazil.
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Francine Ferreira Padilha
  • Francine Ferreira Padilha
  • Tiradentes University, 300 Murilo Dantas Ave, Farolândia, 49032-490 Aracaju, SE, Brazil.
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Margarete Zanardo Gomes
  • Margarete Zanardo Gomes
  • Tiradentes University, 300 Murilo Dantas Ave, Farolândia, 49032-490 Aracaju, SE, Brazil.
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Juliana Cordeiro Cardoso
  • Juliana Cordeiro Cardoso
  • Tiradentes University, 300 Murilo Dantas Ave, Farolândia, 49032-490 Aracaju, SE, Brazil.
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Adriana Andrade Carvalho
  • Adriana Andrade Carvalho
  • Department of Pharmacy, Federal University of Sergipe, Padre Alvares Pitangueira Street 248, 58051-970 Lagarto, SE, Brazil.
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Ricardo Luiz Cavalcanti de Albuquerque-Junior
  • Ricardo Luiz Cavalcanti de Albuquerque-Junior
  • Tiradentes University, 300 Murilo Dantas Ave, Farolândia, 49032-490 Aracaju, SE, Brazil.
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  •  Received: 01 August 2018
  •  Accepted: 30 August 2018
  •  Published: 25 October 2018

References

Akhtar S, Ismail T, Fraternale D, Sestili P (2015). Pomegranate peel and peel extracts: Chemistry and food features. Food Chemistry 174: 417–425.
Crossref

 

Akindele AJ, Wani ZA, Sharma S, Mahajan G, Satti NK, Adeyemi OO, Mondhe DM, Saxena AK (2015). In vitro and in vivo anticancer activity of root extracts of Sansevieria liberica Gerome and Labroy (Agavaceae). Evidence Based Complementary and Alternative Medicine.
Crossref

 

Amaral RG, Fonseca CS, Silva TKM, Andrade LN, França ME, Barbosa-Filho JM, Sousa DP, Moraes MO, Pessoa CO, Carvalho AA, Thomazzi SM (2015). Evaluation of the cytotoxic and antitumour effects of the essential oil from Mentha x villosa and its main compound, rotundifolone. Journal of Pharmacy and Pharmacology 67(8):1100-1106
Crossref

 

Bezerra DP, Castro FO, Alves APNN, Pessoa C, Moraes MO, Silveira ER, Lima MAS, Elmiro FJM, Costa-Lotufo LV (2006). In vivo growth-inhibition of sarcoma 180 by piplartine and piperine, two alkaloid amides from Piper. Brazilian Journal of Medical and Biological Research 39(6):801-807.
Crossref

 

Blowman K, Magalhães M, Lemos MFL, Cabral C, Pires IM (2018). Anticancer Properties of Essential Oils and Other Natural Products. Evidence-Based Complementary and Alternative Medicine.
Crossref

 

Chen HS, Bai MH, Zhang T, Li GD, Liu M (2015). Ellagic acid induces cell cycle arrest and apoptosis through TGF-beta/Smad3 signaling pathway in human breast cancer MCF-7 cells. International Journal of Oncology 46(4):1730-1738.
Crossref

 

Cui Q, Yang DH, Chen ZS (2018). Special Issue: Natural Products: Anticancer and Beyond. Molecules 23:23.
Crossref

 

Dai J, Mumper RJ (2010). Plant Phenolics: Extraction, Analysis and Their Antioxidant and Anticancer Properties. Molecules 15(10):7313-7352.
Crossref

 

Deng Y, Li Y, Yang F, Zeng A, Yang S, Luo Y, Zhang Y, Xie Y, Ye T, Xia Y, Yin W (2017). The extract from Punica granatum (pomegranate) peel induces apoptosis and impairs metastasis in prostate cancer cells. Biomedicine and Pharmacotherapy 93:976-984.
Crossref

 

Deng YL, Li YL, Zheng TT, Hu MX, Ye TH, Xie YM, Yin WY (2018). The Extract from Punica Granatum (Pomegranate) Leaves Promotes Apoptosis and Impairs Metastasis in Prostate Cancer Cells. Sichuan da xue xue bao. Yi xue ban= Journal of Sichuan University. Medical science edition 48(1):8-12.

 

Edderkaoui M, Odinokova I, Ohno I, Gukovsky I, Go VL, Pandol SJ, Gukovskaya AS (2008). Ellagic acid induces apoptosis through inhibition of nuclear factor kB in pancreatic cancer cells. World Journal of Gastroenterology: WJG 14(23):3672.
Crossref

 

Elmore S (2007). Apoptosis: a review of programmed cell death. Toxicologic Pathology 35(4):495-516.
Crossref

 

Evan GI, Vousden KH (2001). Proliferation, cell cycle and apoptosis in cancer. Nature 411(6835):342.
Crossref

 

Fresco P, Borges F, Diniz C, Marques MP (2006). New insights on the anticancer properties of dietary polyphenols. Medicinal Research Reviews 26(6):747-766.
Crossref

 

Fulda S (2009). Apoptosis pathway and their therapeutic explotation in pancreatic cancer. Journal of Cellular and Molecular Medicine 13(7):1221-1227.
Crossref

 

Gonzaga ML, Bezerra DP, Alves AP, de Alencar NM, Mesquita Rde O, Lima MW, Soares Sde A, Pessoa C, de Moraes MO, Costa-Lotufo LV (2009). In vivo growth-inhibition of Sarcoma 180 by an (1→4)-glucan– b-(1→6)-glucan-protein complex polysaccharide obtained from Agaricus blazei Murill. Journal of Natural Medicines 63(1):32-40.
Crossref

 

Hassan M, Watari H, AbuAlmaaty A, Ohba Y, Sakuragi N (2014). Apoptosis and Molecular Targeting Therapy in Cancer. BioMed Research International 2014.
Crossref

 

Jayakumar S, Haridass S, Krishnamurthy V (2012). Anticancer activity of Punica granatum rind extracts against human lung cancer cell line. Asian Journal of Pharmaceutical and Clinical Research 5(2):204-210.

 

Joseph MM, Aravind SR, George SK, Varghese S, Sreelekha TT (2013). A galactomannan polysaccharide from Punica granatum imparts in vitro and in vivo anticancer activity. Carbohydrate Polymers 98(2):1466–1475.
Crossref

 

Li Y, Yang F, Zheng W, Hu M, Wang J, Ma S, Deng Y, Luo Y, Ye T, Yin W (2016). Punica granatum (pomegranate) leaves extract induces apoptosis through mitochondrial intrinsic pathway and inhibits migration and invasion in non-small cell lung cancer in vitro. Biomedicine & Pharmacotherapy 80: 227-235.
Crossref

 

Liang CZ, Zhang X, Li H, Tao LJ, Yang ZR, Zhou XP, Shi ZL, Tao HM (2012). Gallic acid induces the apoptosis of human osteosarcoma cells in vitro and in vivo via the regulation of mitogen-activated protein kinase pathways. Cancer Biotherapy and Radiopharmaceuticals 27(10):701-710.
Crossref

 

Lo C, Lai TY, Yang JH, Yang JS, Ma YS, Weng SW, Chen YY, Lin JG, Chung JG (2010). Gallic acid induces apoptosis in A375.S2 human melanoma cells through caspase-dependent and -independent pathways. International Journal of Oncology 37(2):377-385.

 

Locatelli C, Filippin-Monteiro FB, Creczynski-Pasa TB (2013). Alkyl esters of gallic acid as anticancer agents: a review. European Journal of Medicinal Chemistry 60:233-239.
Crossref

 

Lotufo LV, Pessoa C, de Matos MP, Ramos MV, Moraes MO (2011). Antitumor effect of laticifer proteins of Himatanthus drasticus (Mart.) Plumel – Apocynaceae. Journal of Ethnopharmacology 137(1):421-426.
Crossref

 

Mohammad GJ, Al-Jassani MJ, Hameed IH (2016). Anti-bacterial, antifungal activity and chemical analysis of punica grantanum (Pomegranate peel) using GC–MS and FTIR spectroscopy. International Journal of Pharmacognosy and Phytochemical Research 8(3):480-494.

 

Mousinho KC, Oliveira CC, Ferreira JR, Carvalho AA, Magalhães HI, Bezerra DP, Alves AP, Costa-Mubeen M, Kini SG (2012). A review on the design and development of EGFR tyrosine kinase inhibitors in cancer therapy. International Journal of Therapeutic Applications 5:29-37.

 

Panth N, Manandhar B, Paudel KR (2017). Anticancer Activity of Punica granatum (Pomegranate): A Review. Phytotherapy Research 31(4):568-578.
Crossref

 

Qu W, Breksa III P, Pan Z, Ma H (2012). Quantitative determination of polyphenols constituent in pomergranate products. Food Chemistry 132(3):1585-1591.
Crossref

 

Rayan A, Raiyn J, Falah M (2017). Nature is the best source of anticancer drugs: Indexing natural products for their anticancer bioactivity. PLoS One 12(11):e0187925.
Crossref

 

Redd WH, Montgomery GH, DuHamel KN (2001). Behavioral Intervention for cancer treatment side effects. JNCI: Journal of the National Cancer Institute 93(11):810-823.
Crossref

 

Shirode AB, Kovvuru P, Chittur SV, Henning SM, Heber D, Reliene R (2014). Antiproliferative effects of pomegranate extraction MCF-7 breast cancer cells are associated with reduced DNA repair gene expression and induction of double strand breaks. Molecular Carcinogenesis 53(6):458-470.
Crossref

 

Singh B, Singh JP, Kaur A, Singh N (2018). Phenolic compounds as beneficial phytochemicals in pomegranate (Punica granatum L.) peel: A review. Food Chemistry 261:75-86.
Crossref

 

Vidal A, Fallarero A, Pe-a BR, Medina ME, Gra B, Rivera F, Gutierrez Y, Vuorela PM (2003). Studies on the toxicity of Punica granatum L. (Punicaceae) whole fruit extracts. Journal of Ethnopharmacology 89(2-3):295-300.
Crossref

 

Woodside KJ, Spies M, Wu XW, Song J, Quadeer SS, Daller JA, Wolf SE (2003). Decreased lymphocyte apoptosis by anti-tumor necrosis factor antibody in Peyer's patches after severe burn. Shock 20(1):70-73.
Crossref

 

Zahin M, Ahmad I, Gupta RC, Aqil F (2014). Punicalagin and ellagic acid demonstrate antimutagenic activity and inhibition of benzo[a]pyrene induced DNA adducts. BioMed Research International.
Crossref

 

Zekavat O, Amanat A, Karami M, Paydar S, Gramizadeh B, Zareian-Jahromi M (2016). Wound Healing Studies Using Punica granatum Peel: An Animal Experimental Study. Advances in Skin & Wound Care 29(5):217-225.
Crossref

 

Zhang H, Guo ZJ, Xu WM, You XJ, Han L, Han YX, Dai LJ (2014). Antitumor effect and mechanism of an ellagic acid derivative on the HepG2 human hepatocellular carcinoma cell line. Oncology Letters 7(2):525-530.
Crossref

 

Zhao M, Tang SN, Marsh JL, Shankar S, Srivastava RK (2013). Ellagic acid inhibits human pancreatic cancer growth in Balb c nude mice. Cancer Letters 337(2):210-217.
Crossref