Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Oral Ricinus communis oil exposure at different stages of pregnancy impaired hormonal, lipids profile and histopathology of reproductive organs in Wistar rats

Shakiru Ademola Salami*
  • Shakiru Ademola Salami*
  • Department of Physiology, Lagos State University, College of Medicine, Ikeja, Lagos State, Nigeria.
  • Google Scholar
Yinusa Raji
  • Yinusa Raji
  • Department of Physiology, University of Ibadan, Ibadan, Oyo State, Nigeria.
  • Google Scholar


  •  Received: 15 September 2014
  •  Accepted: 13 November 2014
  •  Published: 25 November 2014

References

Allegri R, Deschel GC, Filippi V, Gibellini M, Portioli E, Veneri D (1981). Proposal for the pharmacopoeia: hydrogenated castor oil translation. Boll. Chim. Farm. 120:557-558.
 
Bergstrom R, Adami HO, Mohner W, Zatonski W, Storm H, Ekbom A, Tretli S, Teppo A, Akre A, Hakulinen T (1996). Increase in testicular cancer incidence in six European countries: a birth cohort phenomenon. J. Natl. Cancer Inst. 88:727-733.
Crossref
 
Boel ME, Lee SJ, Rijken MJ, Paw MK, Pimanpanarak MT, Saw O, Singhasivanon P, Nosten F, McGready R (2010). Castor Oil for Induction of Labor: Not Harmful, Not Helpful. Obstet. Gynecol. Surv. 65(2):77-78.
Crossref
 
Cosmetic Ingredient Review Expert Panel (2007). Final Report on the Safety Assessment of Ricinus communis (Castor) seed Oil, Hydrogenated Castor Oil, Ricinoleic Acid, Potassium Ricinoleate, Sodium Ricinoleate, Zink, and Octyldodecyl Ricinoleate. Glyceryl Ricinoleate, Methyl Ricinoleate, Cetyl Ricinoleate, Ethyl Ricinoleate, Glycol Ricinoleate, Isopropyl Ricinoleate. Int. J. Toxicol. 26(suppl. 3):31-77.
Crossref
 
Davis L (1984). The use of castor oil to stimulate labor in patients with premature rupture of membranes. J. Nurse Midwifery 29:366-370.
Crossref
 
Drugstore.com Inc (2004). Rite Aid Castor oil, stimulant laxative U.S.P. Package details: Directions. http://www.drugstore.com.
 
Foster WG, Lagunova A, Anzarb M, Sadeua JC, Khanb MIR, Bruina JE, Woynillowicza AK, Buhrc M, Hollowaya AC (2011). Effect of in utero and lactational nicotine exposure on the male reproductive tract in peripubertal and adult rats. Reprod. Toxicol. 31:418-423.
Crossref
 
Fowden AL, Giussani DA, Forhead AJ (2006). Intrauterine Programming of Physiological Systems: Causes and Consequences. Physiology 21(1):29-37.
Crossref
 
Garry DR, Figueroa J, Guillaume P, Cucco V (2000). Use of castor oil in pregnancies at term. Altern. Ther. Health Med. 6:77-79.
Pubmed
 
Gottschalck TE, McEwen GN Jr (2004). International Cosmetic Ingre-dient Dictionary and Handbook,10th ed. Washington, DC: CTFA.
 
Green NPO, Stout GW, Taylor DJ (1995). Biological Sciences 2nd Edition. Cambridge University Press.
 
Gustafsson JA (2008). Plant derived ligands of nuclear receptors and their biological effects. Plant Med. 74:1-338.
Crossref
 
Ibironke A Ajayi, Rotimi A Oderinde, Victor O Taiwo and Emmanuel O Agbedana (2004) Dietary effects on growth, plasma lipid and tissues of rats fed with non-conventional oil of Telfairia occidentalis. J. Sci. Food Agric. 84:1715-1721.
Crossref
 
Ihara-Watanabe M, Shiroyama T, Konda G, Umekawa H, Takahashi T, Yamada T, Furuichi Y (1999). Effects of castor oil on lipid metabolism in rats. Biosci. Biotechnol. Biochem. 63:595-597.
Crossref
 
International Programme on Chemical Safety (IPCS) (2002). Global assessment of the state-of-the-science of endocrine disruptors. Geneva: World Health Organization.
 
Kato A, Yamaura Y (1970). A rapid gas chromatographic method for the determination of fatty acid compositions of soybean oil and castor oil. Chem. Ind. 39:1260.
Pubmed
 
Kavlock RJ (1999). Overview of endocrine disruptor research activity in the United States. Chemosphere 39:1227-1236.
Crossref
 
Kenji S, Nikolaos S (1998). Effects of hypercholesterolaemia on testicular function and sperm physiology. Yonago acta Medica 41:23-29.
 
Larsen SW, Rinvar E, Svendsen O, Lykkesfeldt J, Friis GJ, Larsen C (2001). Determination of the disappearance rate of iodine-125 labelled oils from the injection site after intramuscular and subcutaneous administration to pigs. Int. J. Pharm. 230:67-75.
Crossref
 
Leonida F, Daniele DS, Francesco D-F (2007). Altered reproductive success in rat pairs after environmental-like exposure to xenoestrogen. Proc. R. Soc. B. 274:1631-1636.
Crossref
 
Lording DW, De Kretser DM (1972). Comparative ultrastructural and histochemical studies of the interstitial cells of the rat testis during fetal development and postnatal development. J. Reprod. Fert. 29:261-269.
Crossref
 
Lorenz W, Schmal A, Schult H (1982). Histamine release and hypotensive reactions in dogs by solubilizing agents and fatty acids: Analysis of various components in cremophor El and development of a compound with reduced toxicity. Agents Actions 12(1-2):64-80.
Crossref
 
Maier M, Staupendahl D, Duerr HR, Refior HJ (1999). Castor oil decreases pain during extracorporeal shock wave application. Arch. Orthop. Trauma Surg. 119:423-427.
Crossref
 
Masri MS, Goldblatt LA, DeEds F, Kohler GO (1962). Relation of cathartic activity to structural modifications of ricinoleic acid of castor oil. J. Pharm. Sci. 51:999-1002.
Crossref
 
Mitri F, Hofmeyr GJ, Van Geldren CJ (1987). Meconium during labor-self-medication and other associations. SAMJ 431-433.
Pubmed
 
National Toxicology Program (NTP) (1992). NTP technical report on the toxicity studies of castor oil (CAS No. 8001-79-4).
 
National Toxicology Program (NTP) (2003). NTP Chemical Repository. Castor Oil. Research Triangle Park, NC: NTP.
 
Nkpa NN, Arowolo TA, Akpan HJ (1989). Quality of Nigerian palm oil after bleaching with local treated clays. J. Am. Oil Chem. Soc. (JAOCS) 66(2):218-222.
Crossref
 
OECD guideline for testing of chemicals acute oral toxicity-up-and-down procedure 425 adopted: 17th December 2001.
 
Okwuasaba FK, Osunkwo UA, Ekwenchi MM (1991). Anticonceptive and estrogenic effects of a seed extract of Ricinus communis var. minor. J. Ethnopharmacol. 34:141-145.
Crossref
 
Paul H, McCay CM (1942). The utilization of rats by herbivora. Arch. Biochem. 1:247-253.
 
Pradumna J, Amir A, Tarun G, Philip B (2009). Liver function test and pregnancy. J. Matern-Fetal Neonatal Med. 22(3):274-283.
Crossref
 
Rafieiolhossaini M, Adams A, De Kimpe N, Van Damme P (2008). Influence of soil nitrogen level and plant spacing on essential oil content and composition of German chamomile (Matricaria chamomilla). Planta Medica 74:310.
Crossref
 
Raji Y, Oloyo AK, Morakinyo AO (2006). Effect of methanol extract of Ricinus communis seed on reproduction of male rats. Asian J. Androl. 8(1):115-121
Crossref
 
Reithman S, Frankel S (1957). A colorimetric method for determination of serum glutamate oxaloacetate and pyruvate transaminase. Am. J. Clin Pathol. 28: 56-63.
 
Rifai N, Bachorik PS, Albers JJ (1999). Lipids, lipoproteins and apolipoproteins. In: Burtis CA, Ashwood ER (Eds.), Tietz Textbook of Clinical Chemistry. WB Saunders, Philadelphia, Pennsylvania. pp. 809-861.
 
Rodney AR, Bell DR (2009). Medical Physiology Principles for clinical Medicine 3rd Edition Lippincott Williams and Wilkins. pp. 688-725.
 
Sani UM, Sule MI (2007). Anti-Fertility activity of Methanol extracts of Three different seed varieties of Ricinus Communis Linn (Euphorbiaceae). Nig. J. Pharm. Sci. 6:78-83.
 
Savabieasfahani M, Kurunthachalam K, Olga A, Neil PE, Vasantha P (2006). Developmental Programming: Differential Effects of Prenatal Exposure to Bisphenol-A or Methoxychlor on Reproductive Function. Endocrinology 147(12):5956-5966.
Crossref
 
Scarpa A, Guerci A (1982). Various uses of the castor oil plant (Ricinus communis L.). A review. J. Ethnopharmacol. 5:117-137.
Crossref
 
Steingrub JS, Lopez T, Teres D, Steingart R (1988). Amniotic fluid embolism associated with castor oil ingestion. Crit Care Med16:642-643.
Crossref
 
Stump DG, Joseph FH, Sandra RM, Craig HF, Bruno S, Motoki S (2007). An oral two generation reproductive toxicity study of S-111-S-WB in rats. Reprod. Toxicol. 25:7-20.
Crossref
 
Thompson WG (1980). Laxatives: Clinical pharmacology and rational use. Drugs 19:49-58.
Crossref
 
TNO BIBRA International Ltd. (1999). Toxicity profile. Castor oil. Surrey, United Kingdom: TNO BIBRA International Ltd. p. 9.
 
Onwuluri VA, Anekwe GE (2001). Amino acids and other Biochemical components of Ricinus communis (Variety minor), an Anti-conceptive seed. Pak. J. Biol. Sci. 4(7):866-868.
Crossref
 
Watson WC, Gordon RS Jr (1962). Studies on the digestion, absorption and metabolism of castor oil. Biochem. Pharmacol. 11:229-236.
Crossref