Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Podophyllotoxin content in rhizome and root samples of Podophyllum hexandrum Royle populations from Indian Himalayan region

Hemant Pandey
  • Hemant Pandey
  • G.B. Pant Institute of Himalayan Environment and Development, Kosi-Katarmal, Almora- 263 643, Uttarakhand, India. 2Agro Division, Merino Industries Ltd, Achheja, Hapur-245 101, District Ghaziabad, Uttar Pradesh, India.
  • Google Scholar
Anil Kumar
  • Anil Kumar
  • G.B. Pant Institute of Himalayan Environment and Development, Kosi-Katarmal, Almora- 263 643, Uttarakhand, India. 3Department of Biotechnology and Environmental Sciences, TIFAC-Core, Thapar University, Patiala-147 004, Punjab, India.
  • Google Scholar
Lok Man S. Palni
  • Lok Man S. Palni
  • G.B. Pant Institute of Himalayan Environment and Development, Kosi-Katarmal, Almora- 263 643, Uttarakhand, India. 4Biotechnology Department, Graphic Era (Deemed) University, Clement Town, Dehradun- 248 002, Uttarakhand, India.
  • Google Scholar
Shyamal K. Nandi*
  • Shyamal K. Nandi*
  • G.B. Pant Institute of Himalayan Environment and Development, Kosi-Katarmal, Almora- 263 643, Uttarakhand, India.
  • Google Scholar


  •  Received: 19 September 2014
  •  Accepted: 17 February 2015
  •  Published: 03 March 2015

References

Ajani JA, Mansfield PF, Dumas P (1999). Oral etoposide for patients with metastatic gastric adenocarcinoma. Cancer J. Sci. Am. 5:112-114.
Pubmed
 
Bastos JK, Burandt CL, Nanayakkara NPD, Bryant L, McChesney JDJ (1996). Quantitation of aryltetralin lignans in plant parts and among different populations of Podophyllum peltatum by reverse phase high performance liquid chromatography. J. Nat. Prod. 59:406-408.
Crossref
 
Beutner KR, von Krogh G (1990). Current status of podophyllotoxin for the treatment of genital warts. Semin. Dermatol. 9:148-151.
Pubmed
 
Bhadula SK, Singh AP, Lata H, Kuniyal CP, Purohit AN (1996). Genetic resources of Podophyllum hexandrum Royle, an endangered medicinal species from Garhwal Himalaya, India. Plant Genet. Resour. Newsl. 106:26-29.
 
Calstrom K, Hedin PJ, Jansson L, Lerndal T, Lien J, Weitoft T, Axelson M (2000). Endocrine effects of the podophyllotoxin derivative drug CPH 82 (Reumacon) in patients with rheumatoid arthritis. Scand. J. Rheumtol. 29: 89-96.
Crossref
 
Canel C, Dayan FE, Ganzera M, Khan IA, Rimando A, Burandt CL, Moraes RM (2001). High yield of podophyllotoxin from leaves of Podophyllum peltatum by in situ conversion of podophyllotoxin 4-o-β-D glucopyranoside. Planta Med. 67:97-99.
Crossref
 
Chattopadhyay S, Srivastava AK, Bhojwani SS, Bisaria VS (2001). Development of suspension culture of Podophyllotoxin hexandrum for the production of podophyllotoxin. Biotechnol. Lett. 23:2063-2066.
Crossref
 
Ekstrom K, Hoffman K, Linne T, Eriksson B, Glimelius B (1998). Single dose etoposide in advanced pancreatic and billiard cancer: a phase II study. Oncol. Rep. 5:931-934.
Pubmed
 
Fay DA, Ziegler HW (1985). Botanical source differentiation of Podophyllum resin by high performance liquid chromatography. J. Liq. Chromatogr. 8:1501-1506.
Crossref
 
Holm B, Sehested M, Jesen PB (1998). Improved targeting of brain tumours using dexrazoxane rescue of topoisomerase II combined with supra optimal doses of etoposide and tenoposide. Clin. Cancer Res. 4:1367-1373.
Pubmed
 
Kadakade PG (1982). Growth and podophyllotoxin production in callus tissues of Podophyllum peltatum. Plant Sci. Lett. 25:107-115.
Crossref
 
Kitchlu S, Ram G, Koul S, Koul K, Gupta KK, Ahuja A (2011). Podophyllum lignans array of Podophyllum hexandrum Royle populations from semi-desert alpine region of Zanskar valley in Himalayas. Ind. Crop Prod. 33:584-587.
Crossref
 
Lakhanpal NL (1998). ITS (HS) Classifications of export and import items 1997-2002. Ministry of Commerce, Government of India, New Delhi (Appendix 2).
 
Lee KH, Xiao Z (2005). Podophyllotoxin and analogs. In: Anticancer agents from natural products. Cragg GM, Kingston DGI, Newman DJ, editors. Brunner-Rout ledge Psychology Press, Taylor & Francis Group, Boca Raton, Florida, USA. pp. 71-88.
 
Moraes RM, Burandt CL, Ganzera M, Li X, Khan I, Canel C (2000). The American mayapple revisited- Podophyllum peltatum - still a potential cash crop? Eco. Bot. 54(4):471-476.
Crossref
 
Moraes RM, Momm HG, Silva B, Maddox V, Easson GL, Lata H, Ferreia D (2005). Geographic information system method for assessing chemo-diversity in medicinal plants. Planta Med. 71:1-8.
Crossref
 
Nadeem M, Palni LMS, Kumar A, Nandi SK (2007). Podophyllotoxin content, above- and below ground biomass in relation to altitude in Podophyllum hexandrum populations from Kumaun region of the Indian central Himalaya. Planta Med. 73:388-391.
Crossref
 
Nadeem M, Palni LMS, Purohit AN, Pandey H, Nandi SK (2000). Propagation and conservation of Podophyllum hexandrum Royle: An important medicinal herb. Biol. Conserv. 92:121-129.
Crossref
 
Naik PK, Alam MA, Singh H, Goyal V, Parida S, Kalia S, Mohapatra T (2010). Assessment of genetic diversity through RAPD, ISSR and AFLP markers in Podophyllum hexandrum: a medicinal herb from the northwestern Himalayan region. Physiol. Mol. Biol. Plant 16:135-148.
Crossref
 
Pandey H, Nandi SK, Kumar A, Palni UT, Palni LMS (2007). Podophyllotoxin content in Podophyllum hexandrum Royle plants of known age of seed origin and grown at a lower altitude. Acta Physiol. Plant 29(2):121-126.
Crossref
 
Pandey H, Nandi, SK, Palni LMS (2013). Podophyllotoxin content in leaves and stems of Podophyllum hexandrum Royle from Indian Himalayan region. J. Med. Plant Res. 7:3237-3241.
 
Purohit AN, Lata H, Nautiyal S, Purohit MC (1998). Some characteristics of four morphological variants of Podophyllum hexandrum Royle. Plant Genet. Resour. Newsl. 114:51-52.
 
Schacter L (1996). Etoposide phosphate: what, why, where and how? Semin. Oncol. 23:1-7.
Pubmed
 
Sharma TR, Singh BM, Sharma NR, Chauhan RS (2000). Identification of high podophyllotoxin producing biotypes of Podophyllum hexandrum from north-western Himalaya. J. Plant Biochem. Biotechnol. 9:49-51.
Crossref
 
Sharma V (2013). Part based HPLC-PDA quantification of podophyllotoxin in populations of Podophyllum hexandrum Royle "Indian Mayapple" from higher altitude Himalayas. J. Med. Plant Stud. 1:176-183.
 
Stahelin HF, von Wartburg AV (1991). The chemical and biological route from podophyllotoxin glucoside to etoposide: Ninth Cain Memorial Lecture. Cancer Res. 51:5-15.
Pubmed
 
Van Uden W, Pras N, Visser JF, Malingre TM (1989). Detection and identification of podophyllotoxin produced by cell cultures derived from Podophyllum hexandrum Royle. Plant Cell Rep. 8:165-168.
Crossref
 
Ved DK, Kinhal GA, Ravikumar K, Prabhakaran V, Ghate U, Vijaya Sankar R, Indresha JH (2003). Conservation Assessment and Management Prioritization for the Medicinal plants of Himachal Pradesh, Jammu & Kashmir and Uttaranchal. Foundation of Revitalization of Local Health Traditions (FRLHT), Bangalore, India. pp. 1-24.
 
Zheljazkov VD, Cantrell, CL, Astatkie T (2011). Variation in podophyllotoxin concentration in leaves and rhizomes of American may apple (Podophyllum peltatum L.). Ind. Crop Prod. 33:633-637.
Crossref