Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Isolation and analgesic property of lupeol from Diospyros mespiliformis stem bark

Bulus Adzu1*, Ben Ahmed Chindo1,2, Florence David Tarfa3, Oluwakanyinsola Adeola Salawu1 and Ogbaji John Igoli4
1Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development (NIPRD), Abuja, Nigeria. 2Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Kaduna State University (KASU), Kaduna, Nigeria. 3Department of Medicinal Chemistry and Quality Control, NIPRD, Abuja, Nigeria. 4Natural Products Laboratories, Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), University of Strathclyde, Glasgow, UK.
Email: [email protected]

  •  Received: 26 June 2015
  •  Accepted: 28 July 2015
  •  Published: 10 August 2015

References

Adzu B, Amos S, Dzarma S, Muazzam I, Gamaniel KS (2002). Pharmacological evidence favouring the folkloric use of Diospyros mespiliformis Hochst in the relief of pain and fever. J. Ethnopharmacol. 82:191-195.
http://dx.doi.org/10.1016/S0378-8741(02)00179-4
 
Adzu B, Amizan MB, Okhale SE (2014). Evaluation of antinociceptive and anti-inflammatory activities of standardised rootbark extract of Xeromphis nilotica. J. Ethnopharmacol. 158:271-275.
http://dx.doi.org/10.1016/j.jep.2014.10.030
PMid:25446639
 
Bagalkotkar G, Chuan JS, Khalivulla SI, Hamzah AS, Shaari K, Lajis NH, Saad MS, Stanslas J (2011). Isolation and cytotoxicity of triterpenes from the roots of Phyllanthus pulcher Wall Ex Műll Arg (Euphorbiaceae). Afr. J. Pharm. Pharmacol. 5:183-188.
http://dx.doi.org/10.5897/AJMR10.331
 
Belemtougri RG, Constantin B, Cognard C, Raymond G, Sawadogo L (2006). Effects of two medicinal plants Psidium guajava, L (Myrtaceae) and Diospyros mespiliformis L (Ebenaceae) leaf extracts on rat skeletal muscle in primary culture. J. Zhejiang Univ. Sci. B. 7:56-63.
http://dx.doi.org/10.1631/jzus.2006.B0056
PMid:16365927 PMCid:PMC1361761
 
Chen YF, Ching C, Wu TS, Wu CR, Hsieh WT, Tsai HY (2012). Balanophora spicata and Lupeol acetate possess antinociceptive and anti-Inflammatory activities in vivo and in vitro. Evid. Based Complement. Alternat. Med. 2012:371273.
PMid:23243439 PMCid:PMC3518255
 
Chivandi E, Erlwanger KH (2011). Potential usage of African Ebony (Diospyros mespiliformis) seeds in human health in: Nuts and Seeds in Health and Disease Prevention (Preedy VR, Watson RR, Patel VB Eds.), Elsevier B.V., Amsterdam, Netherlands. pp. 147-152.
http://dx.doi.org/10.1016/b978-0-12-375688-6.10016-7
 
De Lima FO, Alves V, Filho JMB, Da Silva Almeida JRG, Rodrigues LC, Soares MBP, Villarreal CF (2013). Antinociceptive effect of lupeol: Evidence for a role of cytokines inhibition. Phytother. Res. 27:1557-1563.
PMid:23208998
 
Dubuission D, Dennis SG (1977). The formalin test: a quantitative studyof the analgesic effect of morphine, meperidine, and brain stem stimulation in rats and cats. Pain 4:161-174.
http://dx.doi.org/10.1016/0304-3959(77)90130-0
 
Etkin NL (1981). A Hausa herbal pharmacopoeia: Biomedical evaluation of commonly used plant medicines. J. Ethnopharmacol. 4:75-98.
http://dx.doi.org/10.1016/0378-8741(81)90021-0
 
Gallo MBC, Sarachine MJ (2009). Biological activities of lupeol. Int. J. Biomed. Pharm. Sci. 3:46-66.
 
Geetha T, Varalakshmi P (2001). Anti-inflammatory activity of lupeol and lupeol linoleate in rats. J. Ethnopharmacol. 76:77-80.
http://dx.doi.org/10.1016/S0378-8741(01)00175-1
 
Hart BA, Amor S, Jonker M (2004). Evaluating the validity of animal models for research into therapies for immune-based disorders. Drug Discov. Today 9:517-521.
http://dx.doi.org/10.1016/S1359-6446(04)03112-5
 
Houghton PJ, Howes MJ, Lee CC, Steventon G (2007). Uses and abuses of in vitro tests in ethnopharmacology: Visualizing an elephant. J. Ethnopharmacol. 110:391-400.
http://dx.doi.org/10.1016/j.jep.2007.01.032
PMid:17317057
 
Igoli OJ, Alexander GI (2008). Friedelanone and other triterpenoids from Hymenocardia acida. Int. J. Phy. Sci. 3:156-158.
 
Lajubutu BA, Pinney RJ, Roberts MF, Odelola HA, Oso BA (1995). Antibacterial activity of diosquinone and plumbagin from the root of Diospyros mespiliformis (Hostch) (Ebenaceae). Phytother. Res. 9:346-350.
http://dx.doi.org/10.1002/ptr.2650090508
 
Mohamed IE, El Nur EE, Choudhary MI, Khan SN (2009). Bioactive natural products from two Sudanese medicinal plants Diospyros mespiliformis and Croton zambesicus. Rec. Nat. Prod. 3:198-203.
 
Normandin S (2007). Claude Bernard and an introduction to the study of experimental medicine: "physical vitalism," dialectic, and epistemology. J. Hist. Med. Allied Sci. 62:495-528.
http://dx.doi.org/10.1093/jhmas/jrm015
PMid:17576723
 
Randall LO, Selitto JJ (1957). A method for measurement of analgesic activity on inflamed tissue. Achiev. Int. Pharm. 111:409-419.
 
Siddique HRS, Saleem M (2011). Beneficial health effects of lupeol triterpenes: A review of preclinical studies. Life Sci. 88:285-293.
http://dx.doi.org/10.1016/j.lfs.2010.11.020
PMid:21118697
 
Still WC, Kahn M, Mitra A (1978). Rapid chromatographic technique for preparative separations with moderate resolution. J. Org. Chem. 43: 2923-2925.
http://dx.doi.org/10.1021/jo00408a041
 
Tjolsen A, Gerge O-G, Hunskaar S, Rosland JH, Hole K (1992). The formalin test: an evaluation of method. Pain 51:3-17.
http://dx.doi.org/10.1016/0304-3959(92)90003-T
 
Vongtau HO, Abbah J, Mosugu O, Chindo BA, Ngazal IE, Salawu OA, Kwanashie HO, Gamaniel KS (2004). Antinociceptive profile of the methanolic extract of Neorautanania mitis root in rats and mice. J. Ethnopharmacol. 92:317-324.
http://dx.doi.org/10.1016/j.jep.2004.03.014
PMid:15138018
 
Zimmermann M (1983). Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16:109-110.
http://dx.doi.org/10.1016/0304-3959(83)90201-4

 

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