Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3786

Review

Polyphenols derived from four indigenous Indian fruits for cancer chemoprevention and chemotherapy

Sutapa Biswas Majee
  • Sutapa Biswas Majee
  • Division of Pharmaceutics, NSHM College of Pharmaceutical Technology, NSHM Knowledge Campus, Kolkata-Group of Institutions, 124 B.L. Saha Road, Kolkata 700053, India.
  • Google Scholar
Vansh Khattry
  • Vansh Khattry
  • Division of Pharmaceutics, NSHM College of Pharmaceutical Technology, NSHM Knowledge Campus, Kolkata-Group of Institutions, 124 B.L. Saha Road, Kolkata 700053, India.
  • Google Scholar
Vaibhav Agarwal
  • Vaibhav Agarwal
  • Division of Pharmaceutics, NSHM College of Pharmaceutical Technology, NSHM Knowledge Campus, Kolkata-Group of Institutions, 124 B.L. Saha Road, Kolkata 700053, India.
  • Google Scholar
Gopa Roy Biswas
  • Gopa Roy Biswas
  • Division of Pharmaceutics, NSHM College of Pharmaceutical Technology, NSHM Knowledge Campus, Kolkata-Group of Institutions, 124 B.L. Saha Road, Kolkata 700053, India.
  • Google Scholar


  •  Received: 30 October 2016
  •  Accepted: 15 December 2016
  •  Published: 16 December 2016

References

Afify AEMR, Fayed SA, Shalaby EA, El-Shemy HA (2011). Syzygium cumini (pomposia) active principles exhibit potent anticancer and antioxidant activities. Afr. J. Pharm. Pharmacol. 5:948-956.

 

Afrin S, Giampieri F, Gasparrini M, Forbes-Hernandez TY, Varela-López A, Quiles JL, Mezzetti B, Battino M (2016). Chemopreventive and therapeutic effects of edible berries: A focus on colon cancer prevention and treatment. Molecules 21:169.
Crossref

 
 

Agroforestry Database 4.0 (2009). Litchi chinensis. Available at: 

View

 
 

Aqil F, Gupta A, Munagala R, Jeyabalan J, Kausar H, Sharma R, Pal Singh I, Ramesh Gupta C (2012). Antioxidant and antiproliferative activities of anthocyanin/ ellagitannin-enriched extracts from Syzygium cumini L. ('jamun', the Indian Blackberry). Nutr. Cancer 64:428-438.
Crossref

 
 

Arrabal SR, Artacho-Cordón F, León J, Román-Marinetto E, Salinas-Asensio MM, Calvente I, Nú-ez MI (2013). Involvement of free radicals in breast cancer. Springer Plus 2:404:12.

 
 

Ayyanar M, Subash-Babu P (2012). Syzygium cumini (L.) Skeels: A review of its phytochemical constituents and traditional uses. Asian Pac. J. Trop. Biomed. 2(3):240-246.
Crossref

 
 

Boeing H, Bechthold A, Bub A, Ellinger S, Haller D, Kroke A, Leschik-Bonnet E, Muller MJ, Oberritter H, Schulze M, Stehle P, Watzl B (2012). Critical review: Vegetables and fruit in the prevention of chronic diseases. Eur. J. Nutr. 51:637-663.
Crossref

 
 

Bonofiglio D, Giordano C, De Amicis F, Lanzino M, Ando S (2016). Natural products as promising antitumoral agents in breast cancer: Mechanisms of action and molecular targets. Mini Rev. Med. Chem. 16:596-604.

 
 

Booker NW, Zuckermann D (2015). Antioxidants and cancer risk: the good, the bad, and the unknown. Available at: 

View

 
 

Borek C (2004). Dietary antioxidants and human cancer. Int. Cancer Ther. 3:333-341.
Crossref

 
 

Chagas VT, França LM, Malik S, Paes AM (2015). Syzygium cumini(L.) skeels: A prominent source of bioactive molecules against cardiometabolic diseases. Front. Pharmacol. Available at: 

View

 
 

Charepalli V, Reddivari L, Vadde R, Walia S, Radhakrishnan S, Vanamala JKP (2016). Eugenia jambolana (Java Plum) fruit extract exhibits anti-cancer activity against early stage human HCT-116 colon cancer cells and colon cancer stem cells. Cancers 8(3):29.
Crossref

 
 

Chaudhuri RK, Lascu Z, Puccetti G (2007). Inhibitory effects of Phyllanthus emblica tannins on melanin synthesis. Cosmet. Toiletries

 
 

Cheng G, Bai Y, Zhao Y, Tao J, Liu Y, Tu G, Ma L, Liao N, Xu X (2000). Flavonoids from Ziziphus jujuba Mill var. spinosa. Tetrahedron 56:8915-8920.
Crossref

 
 

Chunglok W, Utaipan T, Somchit N, Lertcanawanichakul M, Sudjaroen Y (2014). Antioxidant and antiproliferative activities of non-edible parts of selected tropical fruits. Sains Malaysiana 43:689-696.

 
 

Csuk R (2014). Betulinic acid and its derivatives: a patent review (2008- 2013). Expert Opin. Ther.Pat. 24:913-923. Gao QH, Wu CS, Wang M (2013). The Jujube (Ziziphus jujuba Mill.) Fruit: A review of current knowledge of fruit composition and health benefits. J. Agric. Food Chem. 61:3351-3363.

 
 

Halliwell B (2007). Dietary polyphenols: good, bad, or indifferent for your health. Cardiovasc. Res.73:341.
Crossref

 
 

Hoshyar R, Mohaghegh Z, Torabi N, Abolghasemi A (2015). Antitumor activity of aqueous extract of Ziziphus jujube fruit in breast cancer: An in vitro and in vivo study. Asian Pac. J. Reprod. 4:116-122.
Crossref

 
 

Hsu C, Lin CC, Huang CC, Lin Y, Chou JC, Tsia YT, Su JR, Chung YC (2012). Induction of apoptosis and cell cycle arrest in human colorectal carcinoma by litchi seed extract. J. Biomed. Biotechnol. Article ID 341479:7.
Crossref

 
 

Huang F, Zhang R, Yi Y, Tang X, Zhang M, Su D, Deng Y, Wei Z (2014). Comparison of physicochemical properties and immunomodulatory activity of polysaccharides from fresh and dried litchi pulp. Molecules 19:3909-3925.
Crossref

 
 

Ibrahim SR, Mohamed GA (2015). Litchi chinensis: medicinal uses, phytochemistry, and pharmacology. J Ethnopharmacol.174:492-513.
Crossref

 
 

Islam M, Khan SI, Kato-Noguchi H (2013). Allelopathic activity of Litchi chinensis Sonn. Acta Agri. Scand. Section B - Soil Plant. Sci. 63:669-675.

 
 

Ismail T, Calcabrini C, Diaz AR, Fimognari C, Turrini E, Catanzaro E, Akhtar S, Sestili P (2016). Ellagitannins in cancer chemoprevention and therapy. Toxins. Available at: 
Crossref

 
 

Kabera JN, Semana E, Mussa AR, He X (2014). Plant secondary metabolites: Biosynthesis, classification, function and pharmacological properties. J. Pharm. Pharmacol. 2:377-392.

 
 

Kausar H, Jeyabalan J, Aqil F, Chabba D, Sidana J, Singh IP, Gupta RC (2012). Berry anthocyanidins synergistically suppress growth and invasive potential of human non-small-cell lung cancer cells. Cancer Lett. 325:54-62.
Crossref

 
 

Key TJ, Schatzkin A, Willett WC, Naomi E Allen NE (2004). Diet, nutrition and the prevention of cancer. Public Health Nutr. 7:187-200.
Crossref

 
 

Kilari EK, Putta S (2016). Biological and phytopharmacological descriptions of Litchi chinensis. Pharmacogn. Rev.10:60-65.
Crossref

 
 

Kim SH, Ryu HG, Lee J, Shin J, Harikishore A, Jung HY, Kim YS, Lyu HN, Oh E, Baek NI, Choi KY, Yoon HS, Kim KT(2015). Ursolic acid exerts anticancer activity by suppressing Vaccinia-related kinase -1 mediated damage repair in lung cancer cells. Sci. Rep. 5 14570.
Crossref

 
 

Lea M, Ibeh C, Desbordes C, Vizzotto M (2008). Inhibition of growth and induction of differentiation of colon cancer cells by peach and plum phenolic compounds. Anticancer Res. 28:2067-2076.

 
 

Li L, Adams LS, Chen S, Killian C, Ahmed A, Seeram NP (2009). Eugenia jambolana Lam. Berry extract inhibits growth and induces apoptosis of human breast cancer but not non-tumorigenic breast cells. J. Agric. Food Chem. 57:826-831.
Crossref

 
 

Li W, Liang H, Zhang M, Zhang RF, Deng YY, Wei ZC, Zhang Y, Tang XJ (2012). Phenolic profiles and antioxidant activity of Litchi (Litchi chinensis Sonn.) fruit pericarp from different commercially available cultivars. Molecules 17:14954-14967.
Crossref

 
 

Li Y, Sun HY, Yu XY, Liu D, Wan HX (2015). Evaluation of cellular antioxidant and antiproliferative activities of five main Phyllanthus emblica L. cultivars in China. Ind. J. Pharm. Sci. 77:274-282.
Crossref

 
 

Lima GPP, Vianello F, Corrêa CR, da Silva Campos RA, Borguini MG (2014). Polyphenols in fruits and vegetables and its effect on human health. Food Nutr. Sci. 5:1065-1082.
Crossref

 
 

Lin CC, Chung YC, Hsu CP (2013). Anti-cancer potential of litchi seed extract. World J. Exp. Med. 3:56-61.

 
 

Lin S, Yang B, Chen F, Jiang G, Li Q, Duan X, Jiang Y (2012). Enhanced DPPH radical scavenging activity and DNA protection effect of litchi pericarp extract by Aspergillus awamori bioconversion.

 
 

Lin YC, Chang JC, Cheng SY, Wang CM, Jhan YL, Lo IW, Hsu YM, Liaw CC, Hwang CC, Chou CH (2015). New bioactive chromanes from Litchi chinensis. J. Agric. Food Chem. 63:2472-2478.
Crossref

 
 

Litchi seed extract ver. 6.0 JT (2012). Oryza Oil and Fat Chemical Co. Ltd. Japan. www.oryza.co.jp. (Accesses as on December 01, 2016).

 
 

Liu D, Ye X, Jiang Y (2016). Chinese Dates: A Traditional Functional Food. CRC Press.
Crossref

 
 

Lobo V, Patil A, Phatak A, Chandra N (2010). Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn. Rev.4:118-126.
Crossref

 
 

Lv Q, Luo F, Zhao X, Liu Y, Hu G, Sun C, Li X, Chen K (2015) Identification of proanthocyanidins from Litchi (Litchi chinensis Sonn.) pulp by LC-ESI-QTOF-MS and their antioxidant activity. PLoS ONE 10(3):e0120480.
Crossref

 
 

Madhuri S, Pandey G, Verma KS (2011). Antioxidant, immunomodulatory and anticancer activities of Emblica officinalis: An overview. Int. Res. J. Pharm. 2:38-42.

 
 

Mahata S, Pandey A, Shukla S (2013). Anticancer activity of Phyllanthus emblica Linn. (Indian Gooseberry): Inhibition of transcription factor AP-1 and HPV gene expression in cervical cancer cells. Nutr. Cancer 65:88-97.
Crossref

 
 

Patel R, Mahobia NK, Gupta R, Sanandia JR (2012). Pharmacognostical studies of Litchi chinensis Sonn. seeds. Pharm. Technol. Med.1:145-148. 

View.

 
 

Patocka J (2003). Biologically active pentacyclic triterpenes and their current medicine signification. J. Appl. Biomed. 1:7-12.

 
 

Pereira A, Mallya R (2015). Formulation and evaluation of a photoprotectant cream containing Phyllanthus emblica extract phospholipid complex. J. Pharmacogn. Phytochem. 4:232-240.

 
 

Pham-Huy LA, He H, Pham-Huy C (2008). Free radicals, antioxidants in disease and health. Int . J. Biomed. Sci. 4:89-97.

 
 

Position Statement (2010). Fruit, vegetables and cancer prevention, Cancer Council Australia. (www.cancer.org.au).

 
 

Queiroz ER, Abreu CMP, Oliveira KS, Ramos VO, Fraguas RM (2015). Bioactive phytochemicals and antioxidant activity in fresh and dried lychee fractions. Revista Ciência Agronômica. 46:163-169.
Crossref

 
 

Ramya S, Neethirajan K, Jayakumararaj R (2012). Profile of bioactive compounds in Syzygium cumini – A review. J. Pharm. Res.5:4548-4553.

 
 

Saha S, Verma RJ (2015). Antioxidant activity of polyphenolic extract of Phyllanthus emblica against lead acetate induced oxidative stress. Toxicol. Environ. Health Sci. 7:82-90.
Crossref

 
 

Sawant L, Pandita N, Prabhakar B (2010). Determination of gallic acid in Phyllanthus emblica Linn. dried fruit powder by HPTLC. J. Pharm. Bioall. Sci. 2:105-108.
Crossref

 
 

Shanmugam MK, Dai X, Prem Kumar A, Tan BKH (2013). Ursolic acid in cancerprevention and treatment: Molecular targets, pharmacokinetics and clinical studies. Biochem. Pharmacol. 85:1579-1587.
Crossref

 
 

Singh E, Sharma S, Pareek A, Dwivedi J, Yadav S, Sharma S (2011). Phytochemistry, traditional uses and cancer chemopreventive activity 02:176-183.

 
 

Srivastava M, Hegde M, Chiruvella KK, Koroth JJ (2014). Sapodilla plum (Achras sapota) induces apoptosis in cancer cell lines and inhibits tumor progression in mice. Sci. Rep. 4:6147.
Crossref

 
 

Su D, Zhang R, Hou F, Zhang M, Guo J, Huang F, Deng Y, Wei Z (2014). Comparison of the free and bound phenolic profiles and cellular antioxidant activities of litchi pulp extracts from different solvents. BMC Compl. Altern. Med. 14:9:10.

 
 

Sui Y, Zheng Y, Li X, Li S, Xie B, Sun Zl (2016). Characterization and preparation of oligomeric procyanidins from Litchi chinensis pericarp. Fitoter. 112:168-174
Crossref

 
 

Sumalatha D (2013). Antioxidant and antitumor activity of Phyllanthus emblica in colon cancer cell lines. Int. J. Curr. Microbiol. App. Sci. 2:189-195.

 
 

Swami SB, Thakor NJ, Patil MM, Haldankar PM (2012). Jamun (Syzygium cumini (L.)): A review of its food and medicinal uses. Food Nutr. Sci. 3:1100-1117.
Crossref

 
 

Taechakulwanijya N, Weerapreeyakul N, Barusrux S, Siriamornpun S (2013). Apoptosis induction effect of three Jujube cultivars in HepG2 and Jurkat cell lines. Int. J. Biosci. Biochem. Bioinfo. 3:540-544.
Crossref

 
 

Tahergorabi Z, Abedini R, Mitra M, Fard MH, Beydokhti H (2015). "Ziziphus jujuba": A red fruit with promising anticancer activities. Pharmacogn. Rev. 9:99-106.
Crossref

 
 

Thomas R, Butler E, Macchi F, Williams M (2015). Phytochemicals in cancer prevention and management? Brit. J. Med. Pract. 8:a815-823.

 
 

Vance TM, Su J, Fontham ETH, Koo SI, Chun OK (2013). Dietary antioxidants and prostate cancer: A review. Nutr. Cancer 65(6):793-801.
Crossref

 
 

Wang X, Yuan S, Wang J, Lin P, Liu G, Lu Y, Zhang J, Wang W, Wei Y (2006). Anticancer activity of litchi fruit pericarp extract against human breast cancer in vitro and in vivo. Tox. Appl. Pharmacol. 215:168-178.
Crossref

 
 

Wozniak L, Skapska S, Marszalek K (2015). Ursolic acid-a pentacyclic triterpenoid with a wide spectrum of pharmacological activities. Molecules 20:20614-20641
Crossref

 
 

Yang B, Liu P (2014) . Composition and biological activities of hydrolyzable tannins of fruits of Phyllanthus emblica. J. Agric. Food Chem. 62:529-541.
Crossref

 
 

Yıldırım I, Kutlu T (2015). Anticancer agents: Saponin and tannin. Int. J. Biol. Chem. 9:332-340.
Crossref

 
 

Zhang JY, Zhang C (2015). Research progress on the antineoplastic pharmacological effects and mechanisms of litchi seeds. Chin. Med. 6:20-26.
Crossref

 
 

Zhao M, Yang B, Wang J, Liu Y, Yu L, Jiang Y (2007). Immunomodulatory and anticancer activities of flavonoids extracted from litchi (Litchi chinensis Sonn.) pericarp. Int. Immunopharmacol. 7:162-166.
Crossref

 
 

Zhao T, Sun Q, Marques M, Witcher M (2015). Anticancer properties of Phyllanthus emblica (Indian Gooseberry). Oxid. Med. Cellular Longevity. Article ID 950890:7

 
 

Zhu X, Wang J, Ou Y, Han W, Li H (2013). Polyphenol extract of Phyllanthus emblica (PEEP) induces inhibition of cell proliferation and triggers apoptosis in cervical cancer cells. Eur. J. Med. Res. 18(1):46.
Crossref