Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3684

Full Length Research Paper

Effects of aqueous leaf extracts of Tithonia diversifolia and Moringa oleifera on haematological, biochemical and histopathological parameters in albino rats

Onuoha Chikaodiri H.
  • Onuoha Chikaodiri H.
  • Institute of Agricultural Research and Training, Obafemi Awolowo University, Moor Plantation, Ibadan, Oyo State, Nigeria.
  • Google Scholar
Ala Adeola A.
  • Ala Adeola A.
  • Department of Zoology, Physiology Unit, Faculty of Science, University of Ibadan, Oyo State, Nigeria.
  • Google Scholar

  •  Received: 12 February 2020
  •  Accepted: 07 April 2020
  •  Published: 31 July 2020


Adedara IA, Abolaji AO, Odion BE, Okwudi IJ, Omoloja AA (2014). Impairment of hepatic and renal functions by 2,5-hexanedione is accompanied by oxidative stress in rats. Journal of Toxicology Volume 2014 |Article ID 239240, 9 p. 


Adebayo AH, Abolaji AO, Opata TK, Adegbenro IK (2010). Effects of ethanolic leaf extract of Chrysophyllum albidum G. on biochemical and haematological parameters of albino Wistar rats. African Journal of Biotechnology 9:2145-2150.


Agboola AF, Ajayi HI, Ogunbode SM, Majolagbe OH, Adenekun OO, Oguntayo CT, Opaleye RO (2013). Serum biochemistry and haematological indices of broiler chickens fed graded levels of frog (Rana esculata) meal as replacement to fish meal. International Journal of Agriculture and Biosciences 2(5):260-265.


Aguihe PC, Kehinde AS, Fatokun BO, Omotugba SK, Ashifat AA (2014). Effect of enzyme supplementation on haematology and Serum biochemistry of broiler finishers fed cassava peel meal based diets. Tropical Animal Production Investment 17(1):47-51.


Akinmutimi AH (2004). Evaluation of sword bean (Canavalia gladiata) as an alternative feed resources for broiler chickens. Ph.D. Thesis, College of Animal Science, Micheal Okpara University of Agriculture, Umudike, Nigeria.


Akintunde AR, Omage JJ, Bawa GS, Onimisi PA, Samuel I (2017). Haematological parameters and serum biochemistry of Japanese quail chicks (Coturnixcoturnix japonica) fed raw and processed pigeon pea (Cajanus cajan) seed meal based diets. Nigerian Journal of Animal Production 44:89-96.


Anjorin TS, Ikokoh P, Okolo S (2010). Mineral composition of Moringa oleifera leaves, pods and seeds from two regions in Abuja, Nigeria. International Journal of Agricultural Biology 12:431-434.


Asomugha AL, Ezejindu DN, Asomugha RN, Anyabolu AE, Ojukwu PC (2015). Evaluation of toxicity effect of graded doses of Moringa oleifera leaf extract on blood indices using 20 adult Wistar rats. International Journal of Biomedical and Advance Research 6(2):98-102.


Bukirwa H, Orton L (2005). Artesunate plus mefloquine versus mefloquine for treating uncomplicated malaria. Cochrane Database of Systematic Reviews 4:CD004531.


Busani Moyo, Patrick JM, Arnold H, Voster M (2011). Nutritional characterization of Moringa (Moringa oleifera Lam.) leaves. African Journal of Biotechnology 10 (60):12925-12933.


Cunny HE (2004). Toxicity testing. In: Hodgson E, (ed). A textbook on modern toxicology. 3rd edition. A John Wiley & Sons. Inc. Publication pp. 353-384.


Eidi A, Eidi M, Esmaeili E (2006). Antidiabetic effect of garlic (Allium sativum L.) in normal and streptozotocin-induced diabetic rats. Phytomedicine 13: 624-629.


Elagib HAA, Nabiela EM, Abbass SA, Ginawi TAN (2012). Effects of natural spices on plasma proteins in broiler chicks. Journal of Nutrition and Food Science 2:152,


Fakule JO, Abatan M (2007). The toxicological effects of aqueous leaf extract of Tithonia diversifolia Gray in Rats. Journal of Animal and Veterinary Advances 6(10):1223-1226.


Funmilayo IA, Afolayan OM, Adegbolagun BI, Lucky K, Jennifer O, Chiaka A (2016). Antimalarial actions of Lawsonia inermis, Tithonia diversifolia and Chromolaena odorata in combination. Journal of Ethnopharmacology 191:188-194.


Hsu R (2006). Moringa oleifera medicinal and Economic uses. International Course on Economic Botany, National Herbarium, Leiden, The Netherlands.


Ibeh IN (1992). The Response of the Mammalian Reproductive System to Dietary Exposure to Aflatoxin. University of Benin, Benin City, Nigeria.


Kendel EH (2006). Diagonistic value of biochemistry. Clinical Avian Medicine 11:611-630.


Khalafalla MM, Abdellatef E, Dafalla HM, Nassrallah AA, Aboul-Enein KM, Lightfoot DA, El-Deeb FE, El-Shemy HA (2010). Active principle from Moringa oleifera Lam Leaves effective against two leukemias and a hepatocarcinoma. African Journal of Biotechnology 9(49):8467-8471.


Klaassen CS (2008). Principle of toxicology and treatment of poisoning. In: Parker BK, Blumenthal D, Buxton L (eds.). Goodman & Gilman's; Manual of Pharmacology and Therapeutics, McGraw Hill, pp. 1115-1119.


Martin P (2011). Approach to the patient with liver disease. In Goldman L.S. Chafer A.I. Edns Cecil Medicine, 24th ed. Philadelphia, Pa: Saunders Elsevier Chapter 148.


Mary LA, Gikinis MLA, Charles B, Clifford DVM (2008). Clinical laboratory parameters for Crl: WI (Han) Charles River Laboratories.


Nse-Abasi NE, Williams ME, Akpabio U, Edem EAO (2014). Hematological parameters and factors affecting their values. Agricultural Science 2(1):37-47.


Olabode OS, Sola O, Akanbi WB, Adesina GO, Babajide PA (2007). Evaluation of Tithonia diversifolia (hemsl.) A gray for soil improvement. World Journal of Agricultural Sciences 3(4):503-507.


Oyawoye FO, Ogunkule M (1998). Physiological and biochemical effects of raw jack beans on broilers. In Proceedings of Animal Conference of Nigerian Society for Animal Production, Abeokuta, Nigeria. pp. 141-142.


Pierre L (2015). Is Moringa bad for malaria. Malaria World Journal 20:26. The World's Scientific and Social Network for Malaria Professionals. 



Polat U, Yesilbag D, Eren M (2011). Serum biochemical profile of broiler chicken fed diets containing Rosemary and Rosemary volatile oil. Journal of Biology and Environmental Science 5(13):23-30.


Sharp PE, La Regina MC (eds) (1998). The laboratory rats. CRC Press, New York.