Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Effect of Withania somnifera in the treatment of male infertility: A literature review

Maria Yasmin Paz Teixeira
  • Maria Yasmin Paz Teixeira
  • Programa de Pós-Graduação em Nutrição e Saúde, Universidade Estadual do Ceará (UECE), Av. Dr. Silas Munguba 1700, 60714-903, Fortaleza, Ceará, Brasil.
  • Google Scholar
Camilla Oliveira Duarte de Araujo
  • Camilla Oliveira Duarte de Araujo
  • Departamento de Fisiologia - Disciplina de Fisiologia da Nutrição, Universidade Federal de São Paulo (UNIFESP), Rua Botucatu, 862 - 2o andar - Ed. Ciências Biomédicas - Vila Clementino – S/N São Paulo, São Paulo, Brasil.
  • Google Scholar


  •  Received: 31 July 2019
  •  Accepted: 28 October 2019
  •  Published: 30 November 2019

References

Agarwal A, Virk G, Ong C, du Plessis SS (2014). Effect of oxidative stress on male reproduction. World Journal of Mens Health 32(1):1-1.
Crossref

 

Ahmad MK, Mahdi AA, Shukla KK, Islam N, Rajender S, Madhukar D, Ahmad S (2010). Withania somnifera improves semen quality by regulating reproductive hormone levels and oxidative stress in seminal plasma of infertile males. Fertility and Sterility 94(3):989-996.
Crossref

 

Ahmadi S, Bashiri R, Ghadiri-Anari A, Nadjarzadeh A (2016). Antioxidant supplements and semen parameters: An evidence based review. International Journal of Reproductive Biomedicine 14(12):729.
Crossref

 

Aitken RJ (2016). Oxidative stress and the etiology of male infertility. Journal of Assisted Reproduction and Genetics 33(12):1691-1692.
Crossref

 

Ambiye VR, Langade D, Dongre S, Aptikar P, Kulkarni M, Dongre A (2013). Clinical evaluation of the spermatogenic activity of the root extract of Ashwagandha (Withania somnifera) in oligospermic males: a pilot study. Evidence-Based Complementary and Alternative Medicine. Volume 2013, Article ID 571420, 6 pages.
Crossref

 

Ayaz A, Kothandaraman N, Henkel R, Sikka SC (2018). Impact of environmental factors on the genomics and proteomics landscapes of male infertility. In: Bioenvironmental Issues Affecting Men's Reproductive and Sexual Health. Academic Press, pp. 335-353.
Crossref

 

Azgomi RND, Nazemieyh HR, Sadeghi Bazargani H, Fazljou SMB, Nejatbakhsh F, Moini Jazani A, Zomorrodi A (2015). Comparative evaluation of the effects of Withania somnifera with pentoxifylline on the sperm parameters in idiopathic male infertility. Andrologia 50(7):e13041.
Crossref

 

Azgomi NDR, Zomorrodi A, Nazemyieh H, Fazljou SMB, Sadeghi Bazargani H, Nejatbakhsh F, Ahmadi AsrBadr Y (2018). Effects of Withania somnifera on reproductive system: A systematic review of the available evidence. BioMed Research International Volume 2018, Article ID 4076430, pp. 1-17.
Crossref

 

Bisht S, Dada R (2017). Oxidative stress: Major executioner in disease pathology, role in sperm DNA damage and preventive strategies. Frontiers in Bioscience Scholar 9:420-447.
Crossref

 

Chandra AK, Sengupta P, Goswami H, Sarkar M (2012). Excessive dietary calcium in the disruption of structural and functional status of adult male reproductive system in rat with possible mechanism. Molecular and Cellular Biochemistry 364(1-2):181-191.
Crossref

 

Dar NJ, Hamid A, Ahmad M (2015). Pharmacologic overview of Withania somnifera, the Indian ginseng. Cellular and Molecular Life Sciences 72(23):4445-4460.
Crossref

 

Duca Y, Calogero AE, Cannarella R, Condorelli RA, La Vignera S (2019). Current and emerging medical therapeutic agents for idiopathic male infertility. Expert Opinion on Pharmacotherapy 20(1):55-67.
Crossref

 

Durg S, Dhadde SB, Vandal R, Shivakumar BS, Charan CS (2015). Withania somnifera (Ashwagandha) in neuro behavioural disorders induced by brain oxidative stress in rodents: a systematic review and meta-analysis. Journal of Pharmacy and Pharmacology 67(7):879-899.
Crossref

 

Esmaeili V, Shahverdi AH, Moghadasian MH, Alizadeh AR (2015). Dietary fatty acids affect semen quality: a review. Andrology 3(3):450-461.
Crossref

 

Gadelha CS, Maracaja O, Borges P (2015). Utilização de fitoterápicos e plantas medicinais em diferentes segmentos da sociedade. Programa de Pós-Graduação em Sistemas Agroindustriais (Mestrado Profissional) Dissertações, 4(1):50.

 

Gupta A, Mahdi AA, Shukla KK, Ahmad MK, Bansal N, Sankhwar P, Sankhwar SN (2013). Efficacy of Withania somnifera on seminal plasma metabolites of infertile males: a proton NMR study at 800 MHz. Journal of Ethnopharmacology 149(1):208-214.
Crossref

 

Kumar AK, Kumar R, Rahman MS, Iqubal MA, Anand G, Niraj PK, Ali M (2015). Phytoremedial effect of Withania somnifera against arsenic-induced testicular toxicity in Charles Foster rats. Avicenna Journal of Phytomedicine 5(4):355-364.

 

Lohiya NK, Balasubramanian K, Ansari AS (2016). Indian folklore medicine in managing men's health and wellness. Andrologia 48(8):894-907.
Crossref

 

Mahdi AA, Shukla KK, Ahmad MK, Rajender S, Shankhwar SN, Singh V, Dalela D. (2009). Withania somnifera Improves Semen Quality in Stress-Related Male Fertility. Evidence-Based Complementary and Alternative Medicine Volume 2011, Article ID 576962, pp 1-9
Crossref

 

Mahdi AA, Shukla KK, Ahmad MK, Rajender S, Shankhwar SN, Singh V, Dalela D (2011). Withania somnifera improves semen quality in stress-related male fertility. Evidence-Based Complementary and Alternative Medicine. Volume 2011, Article ID 576962, 9 pages.
Crossref

 

Mansouri E, Keshtkar A, Khaki AA, Khaki A (2016). Antioxidant effects of allium cepa and cinnamon on sex hormones and serum antioxidant capacity in female rats exposed to power frequency electric and magnetic fields. International Journal of Womens Health Reproductive Science 4:141-145.
Crossref

 

Nargund VH (2015). Effects of psychological stress on male fertility. Nature Reviews Urology 12(7):373.
Crossref

 

Narinderpal K, Junaid N, Raman B (2013). A Review on pharmacological profile of Withania somnifera (Ashwagandha). Research and Reviews: Journal of Botanical Sciences 2(4):6-14.

 

Nejatbakhsh F, Shirbeigi L, Rahimi R, Abolhassani H (2016). Review of local herbal compounds found in the Iranian traditional medicine known to optimise male fertility. Andrologia 48(8):850-859.
Crossref

 

Sengupta P, Agarwal A, Pogrebetskaya M, Roychoudhury S, Durairajanayagam D, Henkel, R (2018). Role of Withania somnifera (Ashwagandha) in the management of male infertility. Reproductive Biomedicine Online 36(3): 311-326.
Crossref

 

Shukla KK, Mahdi AA, Mishra V, Rajender S, Sankhwar SN, Patel D, Das M (2011). Withania somnifera improves semen quality by combating oxidative stress and cell death and improving essential metal concentrations. Reproductive Biomedicine Online 22(5):421-427.
Crossref

 

Tahvilzadeh M, Hajimahmoodi M, Toliyat T, Karimi M, Rahimi R (2016). An evidence‐based approach to medicinal plants for the treatment of sperm abnormalities in traditional Persian medicine. Andrologia 48(8):860-879.
Crossref

 

Vander Borght M, Wyns C (2018). Fertility and infertility: Definition and epidemiology. Clinical Biochemistry 62:2-10.
Crossref