Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Identification of annotated metabolites in the extract of Centella asiatica

Komal Rani
  • Komal Rani
  • Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India.
  • Google Scholar
Mitali Tyagi
  • Mitali Tyagi
  • Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India.
  • Google Scholar
Akanksha Singh
  • Akanksha Singh
  • Sciex, Gurgaon, India. Sciex - 121, Udyog Vihar, Phase IV, Gurugram, Haryana -122015.
  • Google Scholar
Vairamani Shanmugam
  • Vairamani Shanmugam
  • Centre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai, India.
  • Google Scholar
Annaian Shanmugam
  • Annaian Shanmugam
  • Centre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai, India.
  • Google Scholar
Manoj Pillai
  • Manoj Pillai
  • Sciex, Gurgaon, India. Sciex - 121, Udyog Vihar, Phase IV, Gurugram, Haryana -122015.
  • Google Scholar
Alagiri Srinivasan
  • Alagiri Srinivasan
  • Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India.
  • Google Scholar


  •  Received: 22 November 2018
  •  Accepted: 22 February 2019
  •  Published: 10 March 2019

References

Abdulla MA, Al-Bayaty FH, Younis LT, Hassan A (2010). Anti-ulcer activity of Centella asiatica leaf extract against ethanol-induced gastric mucosal injury in rats. Journal of Medicinal Plant Research 4(13):1253-1259.

 

Albert-García JR, Calatayud JM (2008). Determination of the herbicide benfuresate by its photo-induced chemiluminescence using flow multi commutation methodology. Talanta 75(3):717-724.
Crossref

 
 

Antony B, Santhakumari G, Merina B, Sheeba V, Mukkadan J (2006). Hepatoprotective effect of Centella asiatica (L) in carbon tetrachloride induced liver injury in rats. Indian Journal of Pharmaceutical Sciences 68(6):772-776.
Crossref

 
 

Arora R, Kumar R, Agrawal A, Reeta KH, Gupta YK (2018). Comparison of three different extracts of Centella asiatica for anti-amnesic, antioxidant and anticholinergic activities: in vitro and in vivo study. Biomedicine and Pharmacotherapy 105(2018):1344-1352.
Crossref

 
 

Arumugam T, Muniappan A, Pillai YJK, Sekar T (2011). Phytochemical screening and antibacterial activity of leaf and callus extracts of Centella asiatica. Bangladesh Journal of Pharmacology 6(1):55-60.

 
 

Barnes PM, Powell-Griner E, McFann K, Nahin RL (2004). Complementary and alternative medicine use among adults: United States, 2002. Advance Data 27(343):1-19.
Crossref

 
 

Bown DN, Ríos JR, Del Angel CG, Guerrero JC, Méndez JF (1984). Evaluation of chlorphoxim used against Anopheles albimanus on the south coast of Mexico: 1. Results of indoor chlorphoxim applications and assessment of the methodology employed. Bulletin of Pan American Health Organisation 18(4):379-388.

 
 

Chauhan PK, Pandey IP, Dhatwalia VK (2010). Evaluation of the anti-diabetic effect of ethanolic and methanolic extracts of centella asiatica leaves extract on alloxan induced diabetic rats. Advanced Biomedical Research 4(1):27-30.

 
 

Chauhan PK, Singh V (2012). Acute and subacute toxicity study of the acetone leaf extract of centella asiatica in experimental animal models. Asian Pacific Journal of Tropical Biomedicine 2(2):511-513.
Crossref

 
 

Chen XW, Sneed KB, Pan SY, Cao C, Kanwar JR, Chew H, Zhou SF (2012). Herb-drug interactions and mechanistic and clinical considerations. Current Drug Metabolism 13(5):640-651.
Crossref

 
 

Chen Y, Han T, Qin L, Rui Y, Zheng H (2003). Effect of total triterpenes from Centella asiatica on the depression behavior and concentration of amino acid in forced swimming mice. Zhong yao cai= Zhongyaocai= Journal of Chinese medicinal materials 26(12):870-873.

 
 

Cheng CL, Koo MW (2000). Effects of Centella asiatica on ethanol induced gastric mucosal lesions in rats. Life Sciences 67(21):2647–2653.
Crossref

 
 

Chimbalkar AD, Babu V, Ram B, Mhaske GS (2015). Comparative evaluation of combination of extracts of centella asiatica and glycyrrhiza glabra for presentation of haloperidol induced Catalepsy. American Journal of Ethnomedicine 2(1):53-57.

 
 

Chippada SC, Volluri SS, Bammidi SR, Vangalapati M (2011). In vitro anti inflammatory activity of methanolic extract of Centella asiatica by herb membrane stabilization. Rasayan Journal of Chemistry 4(2):457-460.

 
 

Chivapat S, Chavalittumrong P, Tantisira MH (2011). Acute and sub-chronic toxicity studies of a standardized extract of Centella asiatica ECa 233. Thai Journal of Pharmaceutical Sciences 35(2011):55-64.

 
 

Clarke TC (2018). The use of complementary health approaches among U.S. Adults with a recent cancer diagnosis. The Journal of Alternative and Complementary Medicine 24(2):139-145.
Crossref

 
 

Cove D (2015). The moss Physcomitrella patens. Annual Reviews of Genetics 39(1):339-358.
Crossref

 
 

Cremin PA, Zeng L (2002). High-throughput analysis of natural product compound libraries by parallel LC-MS evaporative light scattering detection. Analytical Chemistry 74(21):5492-5450.
Crossref

 
 

Dam H, Søndergaard E (1953). Comparison of the anticoagulant action of 3-(alpha-p chlorphenyl-beta-acetylethyl)-4-hydroxycoumarin (coumachlor) and dicoumarol in chicks and rats. Acta Pharmacologica et Toxicologica 9(2):137-147.
Crossref

 
 

Dantuluri S, North-Lewis P, Karthik SV (2011). Gotu Kola induced hepatotoxicity in a child – Need for caution with alternative remedies. Digestive and Liver Diseases 43(6):500.
Crossref

 
 

Dash BK, Faruquee H, Biswas S, Alam MJ, Sisir S, Prodhan U (2011). Antibacterial and antifungal activities of several extracts of centella asiatica l. against some human pathogenic microbes. Life Sciences and Medicine Research LSMR-35.

 
 

Deshpande PO, Mohan V, Thakurdesai P (2015). Preclinical safety assessment of standardized extract of Centella asiatica (L.) urban leaves. Toxicology International 22(1):10-20.
Crossref

 
 

Dhawan D, Gupta J (2017). Comparison of different solvents for phytochemical extraction potential from Datura metel plant leaves. International Journal of Biological Chemistry 11(1):17-22.

 
 

Ding JZ, Song CW, Zhang S, Liu JY, Huang RZ (2014). Identification of major components of Xingsusan decoction by HPLC-HR-TOF/MS. Zhong yao cai= Zhongyaocai= Journal of Chinese medicinal materials 37(8):1458-1462.

 
 

Emran T, Dutta M, Uddin MM, Nath A, Uddin MZ (2016). Antidiabetic potential of the leaf extract of Centella asiatica in alloxaninduced diabetic rats. Jahangirnagar University Journal of Biological Sciences 4(1):51-59.
Crossref

 
 

Emran TB, Dutta M, Nasiruddin MM, Nath AK, Ziiauddin MD (2015). Antidiabetic potential of the leaf extract of Centella asiatica in alloxan induced diabetic rats. Jahangirnagar University Journal of Biological Sciences 4(1):51-59.
Crossref

 
 

Fujiki H, Suganuma M, Tahira T, Yoshioka A, Nakayasu M, Endo Y, Shudo K, Takayama S, Moore RE, Sugimura T (1983). New classes of tumor promoters: teleocidin, aplysiatoxin, and palytoxin. Princess Takamatsu Symposium 14(1983):37-45.

 
 

Gao ZH, Don XR, Gao RR, Sun DA (2015). Unusual microbial lactonization and hydroxylation of asiatic acid by Umbelopsis isabellina. Journal of Asian Natural Products Research 17(11):1059-1064.
Crossref

 
 

George M, Joseph L, Ramaswamy (2009). Antidiarrhoeal and antioxidant effects of Centella asiatica extract. Asian Journal of Chemistry 21(4):2957-2962.

 
 

George M, Joseph L, Ramaswamy R (2008). Effect of Centella asiatica extract on nociception, experimental diabetes and hyperlipidemia in mice and rats. International Journal of Biological and Chemical Sciences 2(1):59-65.
Crossref

 
 

Gnanapragasam A, Kumar Ebenezar K, Sathish V, Govindaraju P, Devaki T (2004). Protective effect of Centella asiatica on antioxidant tissue defense system against adriamycin induced cardiomyopathy in rats. Life Sciences 76(5):585-597.
Crossref

 
 

Gohil KJ, Patel JA, Gajjar AK (2010). Pharmacological review on Centella asiatica: A potential herbal cure-all. Indian Journal of Pharmaceutical Scienecs 72(5):546-556.
Crossref

 
 

Gromek K, Drumond N, Simas P (2015). Pharmacovigilance of herbal medicines. International Journal of Risk and Safety in Medicine 27(2):55-65.

 
 

Gulumian M, Yahaya ES, Steenkamp V (2018). African herbal remedies with antioxidant activity: A potential resource base for wound treatment. Evidence-Based Complementary and Alternative Medicine 2018.
Crossref

 
 

Hamid IS, Widjaja NMR, Damayanti R (2016). Anticancer activity of Centella asiatica leaves extract in Benzo(a)pyrene-Induced mice. International Journal of Pharmacognosy and Phytochemical Research 8(1):80-84.

 
 

Hasenbein S, Lawler SP, Geist J, Connon RE (2016). A long-term assessment of pesticide mixture effects on aquatic invertebrate communities. Environmental Toxicology and Chemistry 35(1):218-232.
Crossref

 
 

Haustein KO (1973). Comparison of therapeutic and toxic actions of ouabain, gitoxin and 16-epi-gitoxin on isolated atria at different extracellular potassium concentrations. European Journal of Pharmacology 21(2):195-202.
Crossref

 
 

Hayatsu M, Mizutani A, Hashimoto M, Sato K, Hayano K (2001). Purification and characterization of carbaryl hydrolase from Arthrobacter sp. RC100. FEMS Microbiology Letters 201(1):99-103.
Crossref

 
 

Heinric M, Lee TH (2004). Galanthamine from snowdrop - the development of a modern drug against Alzheimer's disease from local Caucasian knowledge. Journal of Ethnopharmacology 92(2-3):147-162.
Crossref

 
 

Hikiji W, Yamaguchi K, Saka K, Hayashida M, Ohno Y, Fukunaga T (2013). Acute fatal poisoning with Tolfenpyrad. Journal of Forensic and Legal Medicine 20(8):962-964.
Crossref

 
 

Hocaoglu N, Atilla R, Onen F, Tuncok Y (2008). Early-onset pancytopenia and skin ulcer following low-dose methotrexate therapy. Human and Experimental Toxicology 27(7):585-589.
Crossref

 
 

Hossain MG, Alam MK, Rahman S (2005). Anticonvulsant and sedative effect of ethanolic extract of Centella asiatica on albino mice. Hamdard Medicus 48(1):98-101. 

View

 
 

Hyde EG, Carmichael WW (1991). Anatoxin-a(s), a naturally occurring organophosphate, is an irreversible active site-directed inhibitor of acetylcholinesterase (EC3.1.1.7). Journal of Biochemical Toxicology 6(3):195-201.
Crossref

 
 

Idris FN, Nadzir MM (2017). Antimicrobial activity of Centella asiatica on Aspergillus niger and Bacillus Subtilis. Chemical Engineering Transactions 56(2017):1381-1386.

 
 

Jenwitheesuk K, Rojsanga P, Chowchuen B, Surakunprapha P (2018). A prospective randomized, controlled, double-blind trial of the efficacy using centella cream for scar improvement. Evidence Based Complement and Alternative Medicine.
Crossref

 
 

Jiang B, Wang H, Fu QM, Li ZY (2008). The chiral pyrethroid cycloprothrin:stereoisomer synthesis and separation and stereoselective insecticidal activity. Chirality 20(2):96-102.
Crossref

 
 

Jorge OA, Jorge AD (2005). Hepatotoxicity associated with the ingestion of Centella asiatica. Revista Espanola de Enfermedades Digestivas 97(2):115-124.
Crossref

 
 

Kari FW, Mennear JH, Farnell D, Thompson RB, Huff JE (1989). Comparative carcinogenicity of two structurally similar phenylenediamine dyes (HC blue no. 1 and HC blue no. 2) in F344/N rats and B6C3F1 mice. Toxicology 56(2):155-165.
Crossref

 
 

Kim OT, Kim MY, Hong MH, Ahn JC, Hwang B (2004). Stimulation of asiaticoside accumulation in the whole plant cultures of Centella asiatica (L.) urban by elicitors. Plant Cell Reports 23(5):339-344.
Crossref

 
 

Klayman DL, Lin AJ, Acton N, Scovill JP, Hoch JM, Milhous WK, Theoharides AD, Dobek AS (1984). Isolation of artemisinin (qinghaosu) from Artemisia annua growing in the United States. Journal of Natural Products 47(4):715-717.
Crossref

 
 

Koehn FE (2008). High impact technologies for natural products screening. In Natural Compounds as Drugs Volume I (pp. 175-210). Birkhäuser Basel.
Crossref

 
 

Korsnes MS, Espenes A, Hermansen LC, Loader JI, Miles CO (2013). Cytotoxic responses in BC3H1 myoblast cell lines exposed to 1-desulfoyessotoxin. Toxicology in Vitro 27(6):1962-1969.
Crossref

 
 

Korsnes MS, Hetland DL, Espenes A, Aune T (2006). Induction of apoptosis by YTX in myoblast cell lines via mitochondrial signalling transduction pathway. Toxicology in Vitro 20(8):1419-1426.
Crossref

 
 

Kumar A, Dogra S, Prakash A (2009). Neuroprotective Effects of Centella asiatica against intracerebroventricular colchicine-induced cognitive impairment and oxidative stress. International Journal of Alzheimer's Disease Article ID 972178, 8 p.
Crossref

 
 

Kumar V, Babu V, Nagarajan K, Machawal L, Bajaj U (2015). Protective effects of Centella asiatica against isoproterenol-induced myocardial infarction in rats: biochemical, mitochondrial and histological findings. The Journal of Phytopharmacology 4(2):80-86.

 
 

Kumari S, Deori M, Elancheran R, Kotoky J, Devi R (2016). In vitro and In vivo antioxidant, anti-hyperlipidemic properties and chemical characterization of Centella asiatica (L.) extract. Frontiers in Pharmacology 7(2016):400.
Crossref

 
 

Lalitha V, Kiran B, Raveesha KA (2013). Antibacterial and antifungal activity of aqueous extract of Centella asiatica L. against some important fungal and bacterial species. World Journal of Pharmacy and Pharmaceutical Sciences 2(6):4744-4752.

 

Leenheers LH, Ravensberg JC, Kerstens HJ, Jongen MJ (1992). Gas chromatographic determination of the pesticide dodemorph for assessment of occupational exposure. Journal of Chromatographic Science 30(6):228-232.
Crossref

 

Levesque F, Seeberger PH (2012). Continuous-flow synthesis of the anti-malaria drug artemisinin. Angewandte Chemie International Edition England 51(7):1706-1709.
Crossref

 
 

Li S, Blain EJ, Cao J, Caterson B, Duance VC (2014). Effects of the mycotoxin nivalenol on bovine articular chondrocyte metabolism in vitro. PLoS One 9(10):e109536.
Crossref

 
 

Libro R, Giacoppo S, Soundara Rajan T, Bramanti P, Mazzon E (2016). Natural phytochemicals in the treatment and prevention of dementia: An overview. Molecules 21(4):518.
Crossref

 
 

Lobay D (2015). Rauwolfia in the treatment of hypertension. Integrative Medicine: A Clinician's Journal 14(3):40.

 
 

Manasa MR, Sachin ID (2016). Anticonvulsant action of aqueous extract of Centella asiatica and sodium valproate—A comparative study in pentylenetetrazole-induced seizures. National Journal of Physiology, Pharmacy and Pharmacology 6(2):128-131.

 
 

Manyam BV, Dhanasekaran M, Hare TA (2004). Effect of antiparkinson drug HP‐200 (Mucuna pruriens) on the central monoaminergic neurotransmitters. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives 18(2):97-101.

 
 

Maurya KN, Shukla S, Asthana A (2014). Pattern of quantitative inheritance of yield and component traits in opium poppy (Papaver somniferum L.). Genetika 46(2):569-578.
Crossref

 
 

McClure TJ, Mulley RC (1984). Some cytotoxic effects of mixtures of simplexin and huratoxin obtained from the desert rice flower, Pimelea simplex. Toxicon 22(5):775-782.
Crossref

 
 

Mejean A, Paci G, Gautier V, Ploux O (2014). Biosynthesis of anatoxin-a and analogues (anatoxins) in cyanobacteria. Toxicon 91(2014):15-22.
Crossref

 
 

Meulenbeld GJ, Wujastyk D (2001). Studies on Indian Medical History. New Delhi, India: Motilal Banarsidas.

 
 

Miyata T (2007). Pharmacological basis of traditional medicines and health supplements as curatives. Journal of Pharmacological Sciences 103(2):127-131.
Crossref

 
 

Moreno EJ, Puc CA, Cáceres FM, Pena RLM, Gamboa AMM (2005). Two new zinniol-related phytotoxins from Alternaria solani. Natural Product Research 19(6):603-607.
Crossref

 
 

Mörike KL, Gleiter CH (2014). Herbal medicines: when to use or not to use?. Der Internist 55(11):1361-1366.
Crossref

 
 

Nagaraju R, Joshi AK, Rajini PS (2015). Organophosphorus insecticide, monocrotophos, possesses the propensity to induce insulin resistance in rats on chronic exposure. Journal of Diabetes 7(1):47-59.
Crossref

 
 

Nahin RL, Straus SE (2001). Research into complementary and alternative medicine: problems and potential. British Medical Journal 322(7279):161-164.
Crossref

 
 

Narahari RS, Aggithaya GM, Suraj KR (2010). A protocol for systematic reviews of Ayurveda treatments. International Journal of Ayurveda Research 1(4): 254-267.
Crossref

 
 

Nasim SA, Dhir B (2010). Heavy metals alter the potency of medicinal plants. Reviews of Environmental Contamination and Toxicology 203(2010):139-149.
Crossref

 
 

Naz E, Ahmad M (2009). Evaluation of five indigenous medicinal plants of Sindh, Pakistan for their antifungal potential. Pakistan Journal of Scientific and Industrial Research 52(6):328-333.

 
 

Ncube B, Finnie JF, Van Staden J (2013). Dissecting the stress metabolic alterations in in vitro Cyrtanthus regenerants. Plant Physioliology and Biochemistry 65(2013):102-110.
Crossref

 
 

Orhan IE (2012). Centella asiatica (L.) Urban: From traditional medicine to modern medicine with Neuroprotective Potential. Evidence Based Complement and Alternative Medicine 2012:946259.
Crossref

 
 

Park JH, Choi JY, Son DJ, Park EK, Song MJ, Hellström M, Hong JT (2017). Anti-Inflammatory effect of titrated extract of Centella asiatica in phthalic anhydride-induced allergic dermatitis animal model. International Journal of Molecular Sciences 18(4):738.
Crossref

 
 

Patocka J, Bielavský J, Cabal J, Fusek J (2000). 3-Nitropropionic acid and similar nitrotoxins. Acta Medica (Hradec Kralove) 43(1):9-13.

 
 

Pita R, Anadon A, Martinez-Larranaga MR (2003). Neurotoxins with anticholinesterase activity and their possible use as warfare agents. Medicina Clinica (Barc) 121(13):511-517.
Crossref

 
 

Pittella F, Dutra RC, Junior DD, Lopes M, Barbosa NR (2009). Antioxidant and cytotoxic activities of Centella asiatica (L) Urb. International Journal of Molecular Sciences 10(9):3713-3721.
Crossref

 
 

Purohit MP, Wells RE, Zafonte RD, Davis RB, Phillips RS (2012). Neuropsychiatric symptoms and the use of complementary and alternative medicine. PMR: The Journal of Injury, Function, and Rehabilitation 5(1):24-31.
Crossref

 
 

Qureshi M, Mehjabeen, Jahan N, Muhammad S, Mohani N, Wazir A, Baig IA, Ahmad M (2015). Evaluation of neuropharmacological, analgesic and anti-inflammatory effects of the extract of Centella asiatica (Gotu kola) in mice. African Journal of Pharmacy and Pharmacology 9(41):995-1001.
Crossref

 
 

Rahman S, Jamal M, Parvin A, Mahfuz-Al-Mamun M, Islam MR (2011). Antidiabetic activity of Centella asiatica (L.) Urbana in alloxan induced Type 1 diabetic model rats. Journal of Biosciences 19(2011):23-27.

 
 

Rai N, Agrawal RC, Khan A (2014). Centella asiatica extract exhibit anticancer activity against different types of tumours. International Journal of Pure and Applied Biosciences 2(1):122-127. 

View

 
 

Rakotoniriana EF, Munaut F, Decock C, Randriamampionona D, Andriambololoniaina M, Rakotomalala T, Rakotonirina EJ, Rabemanantsoa C, Cheuk K, Ratsimamanga SU, Mahillon J, El-Jaziri M, Quetin-Leclercq J, Corbisier AM (2008). Endophytic fungi from leaves of Centella asiatica: Occurrence and potential interactions within leaves. Antonie van Leeuwenhoek 93(1-2):27-36.
Crossref

 
 

Ramakrishna A, Ravishankar GA (2011). Influence of abiotic stress signals on secondary metabolites in plants. Plant Signal Behavior 6(11):1720-1731.
Crossref

 
 

Rao KV (1993). Taxol and related taxanes. I. Taxanes of Taxus brevifolia bark. Pharmaceutical Research 10(4):521-524.
Crossref

 
 

Ren L, Cao QX, Zhai FR, Yang SQ, Zhang HX (2016). Asiatic acid exerts anticancer potential in human ovarian cancer cells via suppression of PI3K/Akt/mTOR signalling. Journal of Pharmaceutical Biology 54(11):2377-2382.
Crossref

 
 

Rocha FF, Almeida CS, Dos Santos RT, Santana SA, Costa EA, De Paula JR, Vanderlinde FA (2011). Anxiolytic-like and sedative effects of Hydrocotyle umbellata L., Araliaceae, extract in mice. Revista Brasileira de Farmacognosia 21(1):115-120.
Crossref

 
 

Sabaragamuwa R, Perera CO, Fedrizzi B (2018). Centella asiatica (Gotu kola) as a neuroprotectant and its potential role in healthy ageing. Trends in Food Science & Technology 79 (2018):88-97.
Crossref

 
 

Saedder EA, Brock B, Nielsen LP, Bonnerup DK, Lisby M (2014). Identifying high-risk medication: A systematic literature review. European Journal of Clinical Pharmacology 70(6):637-645.
Crossref

 
 

Saha S, Guria T, Sibgha T, Maity TK (2013). Evaluation of analgesic and anti-inflammatory activity of chloroform and methanol extracts of Centella asiatica Linn. ISRN Pharmacology 2013:789613.
Crossref

 
 

Sairam K, Rao CV, Goel RK (2001). Effect of Centella asiatica Linn on physical and chemical induced gastric ulceration and secretion in rats. Indian Journal of Experimental Biology 39(2):137-142.

 
 

Schaeffer WI, Smith NE, Payne PA (1975). Physiological and biochemical effects of the mycotoxin patulin on chang liver cell cultures. In vitro 11(2):69-77.
Crossref

 
 

Schobert R, Biersack B, Knauer S, Ocker M (2008). Conjugates of the fungal cytotoxin illudin M with improved tumour specificity. Bioorganic and Medicinal Chemistry 16(18):8592-8597.
Crossref

 
 

Senthilkumar M (2018). In vitro antifungal activity of bioactive compound of Centella asiatica (L.) urban. In vitro 3(1).

 
 

Senthilkumar N, Varma P, Gurusubramanian G (2009). Larvicidal and adulticidal activities of some medicinal plants against the Malarial Vector, Anopheles stephensi (Liston). Parasitology Research 104(2):237-244.
Crossref

 
 

Sheldon MB, Kotte JH (1957). Effect of Rauwolfia serpentina and reserpine on the blood pressure in essential hypertension; a long-term double-blind study. Circulation 16(2):200-206.
Crossref

 
 

Shen Y (1997). Determination of furanoterpenoid toxins from sweet potato by thin-layer chromatography. Se pu= Chinese journal of chromatography 15(4):328-330.

 
 

Sivakumar V, Sadiq AM, Bharathi SD (2018). Hepatoprotective activity of Centella asiatica linn. against paracetamol induced liver damage in experimental animals. Emergent Life Science Research 4(1):19-26.
Crossref

 
 

Skrbić B (2007). Organochlorine and organophosphate pesticide residues in wheat varieties from Serbia. Food Additives Contaminant 24(7):695-703.
Crossref

 
 

Solfrizzo M, Vitti C, De Girolamo A, Visconti A, Logrieco A, Fanizzi FP (2004). Radicinols and radicinin phytotoxins produced by Alternaria radicina on carrots. Journal of Agricultural and Food Chemistry 52(11):3655-3660.
Crossref

 
 

Somboonwong J, Kankaisre M, Tantisira B, Tantisira MH (2012). Wound healing activities of different extracts of Centella asiatica in incision and burn wound models: an experiment animal study. BMC Complementary and Alternative Medicine 12(1):103.
Crossref

 
 

Somchit MN, Sulaiman MR, Zuraini A, Samsuddin L, Somchit N, Israf DA, Moin S (2004). Antinociceptive and anti-inflammatory effects of Centella asiatica. Indian Journal of Pharmacology 36(4):377-380. 

View

 
 

Sotoudehmanesh R, Anvari B, Akhlaghi M, Shahraeeni S, Kolahdoozan S (2010). Methotrexate Hepatotoxicity in Patients with Rheumatoid Arthritis. Middle East Journal of Digestive Diseases 2(2):104-109.

 
 

Soyingbe OS, Mongalo NI, Makhafola TJ (2018). In vitro antibacterial and cytotoxic activity of leaf extracts of Centella asiatica (L.) Urb, Warburgia salutaris (Bertol. F.) Chiov and Curtisia dentata (Burm. F.) CA Sm-medicinal plants used in South Africa. BMC complementary and alternative medicine 18(1):315.
Crossref

 
 

Sudha S, Kumaresan S, Amit A, David J, Venkataraman BV (2002). Anti-convulsant activity of different extracts of centella asiatica and bacopa monnieri in animals. Journal of Natural Remedies 2(1):33-41.

 
 

Sun H, Dong W, Zhang A, Wang W, Wang X (2012). Pharmacokinetics study of multiple components absorbed in rat plasma after oral administration of stemonae radix using ultra-performance liquid-chromatography/mass spectrometry with automated METABOLYNX software analysis. Journal of Separation Science 35(24):3477-3485.
Crossref

 
 

Sun H, Liu J, Zhang A, Zhang Y, Meng X, Hang Y, Zhang Y, Wang X (2016). Characterization of the multiple components of Acanthopanax Senticosus stem by ultra-high performance liquid chromatography with quadrupole time-of-flight tandem mass spectrometry. Journal of Separation Science 39(3):496-502.
Crossref

 
 

Sushen U, Chouhan A, Ali K, Ranjesh V (2017). Medicinal Properties of Centella asiatica (L.): A review. European Journal of Pharmaceutical and Medicinal Research 4(9):261-268. http://www.ejpmr.com/admin/assets/article_issue/1504173496.pdf

 
 

Telles S, Pathak S, Singh N, Balkrishna A (2014). Research on traditional medicine: what has been done, the difficulties, and possible solutions. Evidence-based Complementary and Alternative Medicine 2014(2014):495635.
Crossref

 
 

Teng L, Jin K, He K, Bian C, Chen W, Fu K, Zhu T, Jin Z (2010). Use of complementary and alternative medicine by cancer patients at Zhejiang University Teaching Hospital Zhuji Hospital, China. African Journal of Traditional, Complementary and Alternative Medicine 7(4):322-30.
Crossref

 
 

Thatishetty AV, Agresti N, O'Brien CB (2013). Chemotherapy-Induced Hepatotoxicity. Clinical Liver Disease 17(4):671-686.
Crossref

 
 

Tokuyama T, Daly J, Witkop B (1969). The structure of batrachotoxin, a steroidal alkaloid from the Colombian arrow poison frog, phyllobatesaurotaenia, and partial synthesis of batrachotoxin and its analogs and homologs. Journal of American Chemical Society 91(14):3931-3938.
Crossref

 
 

Tookey HL, Spencer GF, Grove MD, Kwolek WF (1976). Codeine and morphine in Papaver somniferum grown in a controlled environment. Planta Medica 30(4):331-336.

 
 

Visweswari G, Prasad KS, Chetan PS, Lokanatha V, Rajendra W (2010). Evaluation of the anticonvulsant effect of Centella asiatica (gotu kola) in pentylenetetrazol-induced seizures with respect to cholinergic neurotransmission. Epilepsy & Behavior 17(3):332-335.
Crossref

 
 

Wanasuntronwong A, Tantisira MH, Tantisira B, Watanabe H (2012). Anxiolytic effects of standardized extract of Centella asiatica (ECa 233) after chronic immobilization stress in mice. Journal of Ethnopharmacology 143(2):579-585.
Crossref

 
 

Wang XS, Dong Q, Zuo JP, Fang JN (2003). Structure and potential immunological activity of a pectin from Centella asiatica (L.) Urban. Carbohydrate Research 338(22):2393-2402.
Crossref

 
 

Wang Y, Jin HY, Jiang YB, Sun L, Ma SC (2014). Census of pesticide residues and suggestions for control in traditional Chinese medicine. Zhongguo Zhong yao za zhi= Zhongguo zhongyao zazhi= China journal of Chinese Materia Medica 39(5):807-811.

 
 

Weaver BA (2014). How Taxol/paclitaxel kills cancer cells. Molecular biology of the cell 25(18):2677-2681.
Crossref

 
 

West SD, Weston JH, Day EW (1988). Gas chromatographic determination of residue levels of the herbicides trifluralin, benefin, ethalfluralin, and isopropalin in soil with confirmation by mass selective detection. Association of official analytical chemists 71(6):1082-1085.

 
 

Wijeweea P, Arnason JT, Koszycki D, Merali Z (2006). Evaluation of anxiolytic properties of Gotukola – (Centella asiatica) extracts and asiaticoside in rat behavioral models. Phytomedicine 13(9-10):668-676.
Crossref

 
 

Wishart DS, Knox C, Guo AC, Shrivastava S, Hassanali M, Stothard P, Chang Z, Woolsey J (2006). DrugBank: a comprehensive resource for in silico drug discovery and exploration. Nucleic Acids Research, 34(1):668-72.
Crossref

 
 

Yabe K, Matsushima K, Koyama T, Hamasaki T (1994). Purification and characterization of o-methyltransferase i involved in conversion of demethylsterigmatocystin to sterigmatocystin and of dihydrodemethylsterigmatocystin to dihydrosterigmatocystin during aflatoxin biosynthesis. Applied and Environmental Microbiology 64(1):166-171.

 
 

Yoosook C, Bunyapraphatsara N, Boonyakiat Y, Kantasuk C (2000). Anti-herpes simplex virus activities of crude water extracts of Thai medicinal plants. Phytomedicine 6(6): 411-419.
Crossref

 
 

Zhang FS, Lv YL, Zhao Y, Guo SX (2013). Promoting role of an endophyte on the growth and contents of kinsenosides and flavonoids of Anoectochilus formosanus Hayata, a rare and threatened medicinal Orchidaceae plant. Journal of Zhejiang University Science B 14(9):785-792.
Crossref

 
 

Zhang Q, Liu C, Wu N, Wu X, Li S (2014). Determination of propargite, tebuconazole and bromopropylate pesticide residues in Taiwan green jujubes by gas chromatography-tandem mass spectrometry. Se pu= Chinese journal of chromatography 32(8):886-889.
Crossref

 
 

Zheng HM, Choi MJ, Kim JM, Cha KH, Lee KW, Park YH, Hong SS, Lee DH (2016). Centella asiatica leaf extract protects against indomethacin-induced gastric mucosal injury in rats. Journal of Medicinal Food 19(1):38-46.
hCrossref

 
 

Zhu J, Wu L, Zhang Q, Chen X, Liu X (2012). Investigation the interaction of Daphnin with human serum albumin using optical spectroscopy and molecular modeling methods. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 95(2012):252-257.
Crossref