Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Review

A review on therapeutic potential of Nigella sativa (kalonji) seeds

S. V. Tembhurne
  • S. V. Tembhurne
  • Sudhakarrao Naik Institute of Pharmacy Pusad, Dist: Yavatmal 445204. (M.S), India.
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S. Feroz
  • S. Feroz
  • Bombay College of pharmacy, Kalina Santacruz (East) Mumbai 400098, India.
  • Google Scholar
B. H. More
  • B. H. More
  • Tasgaonkar college of Pharmacy Bhivpuri Dist. Raigarh, India.
  • Google Scholar
D. M.Sakarkar
  • D. M.Sakarkar
  • Sudhakarrao Naik Institute of Pharmacy Pusad, Dist: Yavatmal 445204. (M.S), India.
  • Google Scholar


  •  Accepted: 14 April 2011
  •  Published: 17 January 2014

References

Abdel-Fattah AM, Matsumoto K, Watanabe H (2000). Antinociceptive effects of Nigella sativa oil and its major component, thymoquinone, in mice. Eur. J. Pharmacol. 14(1):89-97.
Crossref
 
Abdel-Sater KA (2009). Gastroprotective effects of Nigella sativa oil on the formation of stress gastritis in hypothyroidal rats. Int. J. Physiol. Pathophysiol. Pharmacol. 1:143-149.
Pubmed
 
Abdel-Wahhab MA, Aly SE (2005). Antioxidant property of Nigella sativa (black cumion) and syzygium aromaticum (colve) in rats during of latoxicosis. J. Appl. Toxical. 25:218-223.
Crossref
 
Abdulelah HAA, Zainal-Abidin BAH (2007). In vivo anti-malarial tests of Nigella sativa (Black Seed) different extracts. Am. J. Pharmacol. Toxicol. 2:46-50.
Crossref
 
Abou Gabal AA, Essawy AE, Abdel-Moneim AM, Hamed SS, Elzergy AA (2007). The protective effect of black seed (Nigella sativa) against carbon tetrachloride-induced chromosomal aberrations and ultrastructural changes of bone marrow cells. Arab J. Biotech. 10(2):275-288. View
 
AbuElEzz NM (2005). Effect of Nigella sativa and Allium cepa oils on Trichinella spiralis in experimentally infected rats. J. Egypt. Soc. Parasit. 35:511-523.                                           Pubmed
 
Ahmad Z, Gafoor A, Aslam M (2004). Nigella sativa – A potential commodity in crop diversification traditionally used in health care. Project on Introduction of Medicinal herb and species as crop. Ministry of food, agriculture and livestock, Pakistan.
 
Al-Awadi FM, Fatania H, Shamte U (1991). The effect of a plant mixture extract on liver gluconeogenesis in streptozotocin-induced diabetic rats. Diab. Res. 18(4):163-168.             Pubmed
 
Al-Awadi FM, Gumma KA (1987). Studies on the activity of individual plants of an anti-diabetic plant mixture. Acta. Diabetol. Lat. 24(1):37-41.
Crossref
 
Al-Ghamdi MS (2001) Anti-inflammatory, analgesic and anti-pyretic activity of Nigella sativa. J. Ethnopharmacol. 76:45-48.
Crossref
 
Al-Hader A, Aqel M, Hasan Z (1993). Hypoglycemic effect of volatile oil of Nigella sativa seeds. Int. J. Pharmacog. 31(2):96-100.
Crossref
 
Ali BH (2004). The effect of Nigella sativa in gentamicin nephrotoxicity in rats. Am. J. Chin. Med. 32(1):49-55.
Crossref
 
Al-Jishi SA, Hoziafa BA (2003). Effect of Nigella sativa on Blood hemostatic functions in rats. J. Ethnopharmacol. 85:7-14.
Crossref
 
Al-Sa'aidi JAA, Al-Khuzai ALD, Al-Zobaydi NFH (2009). Effect of alcoholic extract of Nigella sativa on fertility in male rats. Iraqi. J. Vet. Sci. 23:123-128.                                                               View
 
Al-Shebani WH, Al-Tahan FJ (2009). Antinociceptive effect of watery suspension of Nigella sativa Linn. seeds in mice. Iraqi. J. Vet. Sci. 23:245-248.                                                                     View
 
Amr EE (2009). Anti-Cancer Properties of Nigella spp. Essential Oils and their Major Constituents, Thymoquinone and β-Elemene. Cur. Clin. Pharmacol. 4:43-46.
Crossref
 
Ansari AA, Hassan S, Kenne L, Atta-ur-Rehman S, Wehler T (1988). Structural studies on a saponin isolated from Nigella sativa. Phytochem. 27(12):3977-3979.
Crossref
 
Aqel M, Shaheen R (1996). Effect of the oil of Nigella sativa seed on the uterine smooth muscle of rat and guinea pig. J. Ethnopharmacol. 52(1):23-26.
Crossref
 
Ata-ur-Rehman S, Malik S, Ahmed I, Habib-ur-Rehman (1985). Nigellimine-N-Oxide, a new isoquinoline alkaloid from seeds of Nigella sativa. Heterocycles. 23:953-955.
Crossref
 
Atef M, Al-Attar, Wafa'a A, Al-Taisan (2010). Preventive Effects of Black Seed (Nigella sativa) extract on Sprague Dawley Rats Exposed to Diazinon. Austr. J. Basic Appl. Sci. 4(5):957-968. View
 
Atta-ur-Rehman S, Malik S, Cun-Hung H, Clardy J (1985a). Isolation and structure determination of nigellicine, a novel alkaloid from seeds of Nigella sativa. Tetrahedron Lett. 26:2759-2762.
Crossref
 
Atta-ur-Rehman S, Malik S, Sadiq H, Choudhary MI, Clardy J (1995). Nigellidine, a new indazole alkaloid from seeds of Nigella sativa. Tetrahedron Lett. 36:1993-1996.
 
Ayaz E, Yilmaz H, Ozbek H, Tas Z, Orunc O (2007). The effect of Nigella sativa oil against Aspiculuris tetraptera and Hymenolepis nana in naturally infected mice. Saudi Med. J. 28:1654-1657.
Pubmed
 
Babayan VK, Koottungal D, Halaby GA (1978). Proximate analysis, fatty acid and amino acid composition of Nigella sativa L seeds. J. Food Sci. 43(4):1314-1315.
Crossref
 
Badary A, Taha RA, Ayman M, El-Din G, Abdel-Wahab MH (2003). Thymoquinone is a potent suprroxide anion scavenger. Drug Chem. Toxicol. 26(2):87-98.
Crossref
 
Badary OA (1996). Thymoquinone attenuates afosfamide-induced Fanconi syndrome in rats and enhances its antitumor activity in mice. J. Ethnopharmacol. 67:135-142.
Crossref
 
Badary OA, Gamal-el-Din AM (2001). Inhibitory effect of thymoquinone against 20-methylcholanthrene–induced fibrosarcoma tumorigenesis. Cancer Detect. Prev. 25:362-368.
Pubmed
 
Bahram PG, Vahideh EA, Maryam R, Abolfazl G (2009). Effect of dietary supplementation with Nigella sativa L. on serum lipid profile, lipid peroxidation and antioxidant defense system in hyperlipidemic rabbits. J. Med. Plants Res. 3(10):815-821.                                                       View
 
Banerjee S, Azmi AS, Padhye S, Singh MW, Baruah JB, Philip PA, Sarkar FH, Mohammad RM (2010). Structure-Activity Studies on Therapeutic Potential of Thymoquinone Analogs in Pancreatic Cancer. Pharm. Res. 27(6):1146-1158.
Crossref
 
Chakarvarti N (1993). Inhibition of histamine release from mast cells by nigellone. Ann. Allergy. 70(3):237-242.
 
Chevallier A (1996). Encyclopedia of medicinal plants. New York, NY: DK Publishing. p. 237.
 
Chopra RN, Nayyer SL, Chopra IC (1956). Glossary of Indian medicinal plants. India: CSIR. pp. 176-188.
 
Daba MH, Abdel-Rehman MS (1998). Hepatoprotective activity of thymoquinone in isolated rat hepatocytes. Toxicol. Lett. 95:23-29.
Crossref
 
Datau EA, Eko E, Surachmanto, Pandelaki K, Langi FA (2010). Efficacy of Nigella sativa on Serum Free Testosterone and Metabolic Disturbances in Central Obese Male. Acta. Med. Indones. 42(3):130-34
Pubmed
 
Demir H Kanter, Coskun O, Uz YH, Koe A, Yildiz A (2006). Effect of black cumin (Nigella sativa) on heart rate, some hematological value, and pancreatic beta-cell damage in cadmium-treated rats. Biol. Trace. Elem. Res. 110:151-162.
Crossref
 
Drozed AG, Komissarenko FN, Litvinenko EA (1973). Coumarins of some species of Ranunaulaceae family. Farm ZH. 25(4):57-60.
 
El-Dakhakhani M, El-Halim MA, Aly SM (2000). Effect of Nigella sativa oil on gastric secretion and ethanol-induced ulcer in rats. J. Ethnopharmacol. 72(1-2):299-304.
Crossref
 
El-DakhaKhani M, Mady NL, Halim MA (2000). Nigella sativa L. oil protects against induced hepatotoxicity and improves serum lipid profile in rats. Arzneimittelforschung. 50(9):832-836.
Pubmed
 
El-Dakhakhany M (1963). Studies on the chemical constitution of Egyptian N. sativa L. seeds. Planta Med. 11(4):465-470.
Crossref
 
El-Dakhakhany M (1965). Studies on the Egyptian Nigella sativa L: Some pharmacological properties of its seed's active principle in comparison to its dihydro-compound and its polymer. Arzneim Forsch. Drug Res. 15:1227-1229.  
 
EL-Dakhakhany M (1982). Some pharmacological properties of some constituents of Nigella sativa L seeds: The carbonyl fraction of essential oil. Proceeding of the 2nd International conference on Islamic Medicine, Kuwait. pp. 426-431.
 
El-Dally ES (1996). Protective effect of cysteine, Vitamin E, C. Sativus and N. sativa extract on cisplatin induced toxicity in rats. J. Isl. Acad. Sci. 9(4):47-55.                                                       View
 
El-Hadi MA, Bakri YM, Yousif G (2010). Mohammed and Hassan S. Khalid. Antiplasmodial Activity of Some Medicinal Plants Used in Sudanese Folk-medicine. Environ. Health Insights. 4:1-6.   Pubmed
 
El-Kadi, Kandil O (1986). Effect of Nigella sativa (the black seed) on immunity. Proceeding of the 4th International Conference on Islamic Medicine, Kuwait. Bull. Islamic Med. 4:344-348.
 
El-Kamali HH, Ahmad AH, Mohammad AS, Yahia AAM (1998). Antibacterial properties of essentials oils from Nigella sativa. Fitoterapia. 69:77-78.
 
El-Naggar ARM, El-Deib AEM (1992). A study of some biological activities of Nigella sativa (black seeds) "Habbat El-Barka". J. Egypt Soc. Pharmacol. Exp. Ther. 11(2):781-800.
 
ElShenawy NS, Soliman MF, Reyad SI (2008). The effect of antioxidant properties of aqueous garlic extract and Nigella sativa as anti-schistosomiasis agents in mice. Rev. Inst. Med. Trop. 50:29-36.                                                                                                                                       Pubmed
 
El-Tahir KE, Ashour M, Al-Harbi MM (1993). The respiratory effects of the volatile oil of black seed (Nigella sativa) in guinea pigs: elucidation of the mechanism(s) of action. Gen. Pharmacol. 24(5):1115-1122.
Crossref
 
El-Tahir KE, Ashour MM, Al-Harbi MM (1993). The cardiovascular effects of the volatile oil of black seed (Nigella sativa) in rats: elucidation of the mechanism(s) of action. Gen. Pharmacol. 24(5):1123-1131.
Crossref
 
El-Zawahry BH (1964). Isolation of new hypotensive fraction from Nigella sativa seed. Kongr. Pharm. Wiss. 23:193-203.
 
El-Zawahry BH (1997). Chemical composition of Nigella sativa Linn seed. In: effect of Nigella sativa on certain aspects of metabolism after feeding normal and hyperlipedemic diet in adult and old animals [MD thesis in medical basic sciences]. Cairo, Egypt: Al-Azhar University. pp. 16-28.
 
Enomoto S, Asano R, Iwahori Y, Narui T, Okada Y, Singab AN, Okuyama T (2001). Hematological studies on black cumin oil from the seeds of Nigella sativa L. Biol. Pharm. Bull. 24(3):307-310.
Crossref
 
Eyad MS, Talay Y, Abdullah OB, Abdulaziz Al-Quorain, Mohamed IY, Raed M A, Muhammad AR (2010). Comparative study of Nigella sativa and triple therapy in Eradication of helicobacter pylori in Patient with Non-ulcer dyspepsia. Saudi J. Gastroenterol. 16(30):207-214.           Pubmed
 
Fahrettin Y, Sacit C, Alpaslan T, Mustafa A, Nurten A, Hale C, Ali RO, Muharrem B (2008). Nigella sativa relieves the deleterious effects of ischemia reperfusion injury on liver. World J. Gastroenterol. 14(33):5204-5209.
Crossref
 
Farah IO, Begum RA (2003). Effect of Nigella sativa and oxidative stress on the survival pattern of MCF-7 breast cancer cells. Biomed. Sci. Instrum. 39:359-364.
Pubmed
 
Farah KM, Atoji Y, Shimizu Y, Takewaki T (2002). Insulinotropic properties of Nigella sativa oil in streptozotocin plus nicotinamide diabetic hamsters. Res. Vet. Sci. 73:279-282.
Crossref
 
Gad AM, El-Dakhakhany M, Hassan MM (1963). Studies on the chemical constitution of Egyptian Nigella sativa L oil. Planta Med. 11(2):134-138.
Crossref
 
Gali-Muhtasib H, Roessner A, Schneider-Stock R (2006). Thymoquinone: a promising anti-cancer drug from natural sources. Int. J. Biochem. Cell Biol. 38(8):1249-1253.
Crossref
 
Ghanya Al-Naqeep, Adel S, Al-Zubairi, Maznah I, Zulkhairi HA, Norhaizan ME (2010). Antiatherogenic Potential of Nigella sativa Seeds and Oil in Diet-Induced Hypercholesterolemia in Rabbits. Evid. Based Complement Alternat. Med. 2011:8.                                                       Pubmed
 
Ghaznavi KM (1991). Tibbe-e-Nabvi aur Jadid Science, Al-Faisal Nasheeran wa Tajeera-e- Kutab. Urdu Bazar Lahore, Pakistan. 1:228-236.
 
Ghoneim MT, El-Gindy AR, El-Alami R, Shoukry E, Yaseen S (1982). Possible effects of some extracts of Nigella sativa L seeds on blood coagulation system and fibrinolytic activity. Proceeding of 2nd International Conference on Islamic Medicine 12th Apr, Kuwait. pp. 528-535.
 
Ghosheh OA, Houdi AA, Crooks PA (1999). High performance liquid chromatographic analysis of the pharmacologically active quinones and related compounds in the oil of the black seed (Nigella sativa L.). J. Pharm. Biomed. Anal. 19(5):757-762.
Crossref
 
Gilani AH, Aziz N, Khurram IM, Chaudhary KS, Iqbal A (2001). Bronchodilator, spasmolytic and calcium antagonistic activities of Nigella sativa seed (Kalonji): a traditional herbal product with multiple medicinal uses. J. Pakistan Med. Assoc. 51(3):115-120.
Pubmed
 
Hajhashemi V, Ghannadi A, Jafarabadi H (2004). Black cumin seed essential oil as a potential analgesic and anti-inflammatory. Phytother. Res. 18(3):195-199.
Crossref
 
Haq A, Abdullatif M, Lobo PI, Khabar KS, Sheth KV, Al-Sedairy ST (1995). Nigella sativa: Effect on human lympocytes and polymorphonuclear leucocyte phagocytic activity. Immunopharmacol. 30(2):147-150.
Crossref
 
Haq A, Lobo I, Al-Tufail M, Rama NR, Sedairy ST (1999). Immunomodulatory effect of Nigella sativa proteins fractionated by ion exchange chromatography. Int. J. Immunopharmacol. 21:283-285.
Crossref
 
Haq A, Lobo PI, Al-Tufail M, Rama NR, Sedairy ST (1999). Immunomodulatory effect of Nigella sativa proteins fractionated by ion exchange chromatography. Int. J. Immunopharmacol. 21:283-285.
Crossref
 
Hosseinzadeh H, Parvardeh S (2004). "Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice." Phytomed. 11(1):56-64.
Crossref
 
Hosseinzadeh H, Parvardeh S, Nassiri-Asl M, and Mansouri MT (2005), "Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats," Med. Sci. Monitor 11(4):106-110.
 
Houghton PJ, Zarka R, Heras B, Hoult JR (1995). Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation. Planta Med. 61:33-36.
Crossref
 

Inayat UB, Fazal UR, Muhannad AK, Sarfaraz Khan (2009). Effect of Prophetic medicinal Kalonji (Nigella sativa L.) on Lipid Profile of Human Being: An In vivo Approach. World Appl. Sci. J. 6(8):1053-1057.  

View

 
Jameel A, Rahat AK, Ashraf MM (2009). Study of Nigella sativa oil in the management of wheeze associated lower respiratory tract illness in children. Afr. J. Pharm. Pharmacol. 3(5):248-251.   View
 
Keshri G, Singh MM, Lakshami V, Kamboj VP (1995). Post-coital contraceptive effect of the seeds of Nigella sativa in rats. Indian J. Physiol. Pharmacol. 39(1):59-62.
Pubmed
 
Khadiga A, Abdel Ati AE, Mustafa HE (2009). The effect of dietary Nigella sativa seeds on the blood cholesterol and lipoprotein levels of rabbits. J. Animal Plant Sci. 3(3):227-230.
 
Khaled A, Abdel-Sater (2009). Gastroprotective effects of Nigella sativa oil on the formation of stress gastritis in hypothyroidal rats. Int. J. Physiol. Pathophysiol. Pharmacol. 1:143-149.       View
 
Khanna T, Zaidi FA, Dandiya PC (1993). CNS and analgesic studies of Nigella sativa . Fitoterapia. 5:407-410.
 
Khanna T, Zaidi FA, Dandiya PC (1993). CNS and analgesic studies of Nigella sativa. Fitoterapia. 5: 407-410(1993)
 
Kruk I, Michalska T, Klanda A (2000). The effect of thymol and its derivatives on reaction generating reactive oxygen species. Chemosphere 41:1059-1064.
Crossref
 
Kumara SS, Huat BT (2001). Extraction, isolation and characterization of anti-tumour principle, alpha-hedrin, from the seeds of Nigella sativa. Planta Med. 67:29-22.
Crossref
 
Kumara SS, Huat BT (2001). Extraction, isolation and characterization of anti-tumour principle, alpha-hedrin, from the seeds of Nigella sativa. Planta Med. 67:29-22.
Crossref
 
Le PM, Benhaddou-Andaloussi A, Settaf A, Cherrah Y, Haddad PS (2004). The petroleum ether extract of Nigella sativa exerts lipid lowering action in the rats. J. Ethanopharmacol. 94(2-3):251-259.
Crossref
 
Mahfouz M, El-Dakhakhany M (1960). Some chemical and pharmacological properties of the new antiasthmatic drug "Nigellone". Egypt Pharmacol. Bull. 42:411-424.
 
Mahmoud MR, El-Abhar HS, Salh S (2002). The effect of Nigella sativa oil against the liver damage induced by Schistosoma mansoni infection in mice. J. Ethnopharmacol. 79(1):1-11.
Crossref
 
Matira K, Zesmin FD (2008). Effects of the crude and the n-hexane extract of Nigella sativa Linn. (kalajira) upon diabetic rats. Bangladesh J. Pharmacol. 4:17-20.
 
Merfort I, Wary V, Barakat H, Hussain A, Nawwar AM (1997). Flavonoltriglycosides from seeds of Nigella sativa. Phytochemistry 46(2):359-363.
Crossref
 
Mohamed AM, EL-Sharkawy FZ, Ahmed SAA, Aziz WM, Badary OA (2009). Glycemic Control and Therapeutic Effect of Nigella sativa and Curcuma longa on Rats with streptozotocin-induced Diabetic Hepatopathy. J. Pharmacol. Toxicol. 4(2):45-57.
Crossref
 
Mohammad H, Boskabady, Javad F (2008). The Possible Prophylactic Effect of Nigella sativa Seed Aqueous Extract on Respiratory Symptoms and Pulmonary Function Tests on Chemical War Victims: A Randomized, Double-Blind, Placebo-Controlled Trial. J. Altern. Complement. Med. 14(9):1137-1144.                                                                                                                      View
 
Muhammad AB, Muhammad T (2007). Effect of Nigella sativa on Lipid Profile in Albino rats. Gomal J. Med. Sci. 5(1):28-31.
 
Mukhallad AM, Mohamad MJ, Mohamad P, Hatham D (2009). Effects of Black Seeds (Nigella sativa) on Spermatogenesis and Fertility of Male Albino Rats. Res. J. Med. Med. Sci. 4(2):386-390. View
 
Nadia MH, Taha RA (2009). Effects of Nigella sativa Oil and Thymoquinone on Oxidative Stress and Neuropathy in Streptozotocin-Induced Diabetic Rats. Pharmacology 84:127-134.
Crossref
 
Nagi MN, Alam K, Badary OA, Al-Shabanah OA, Al-Sawaf HA, AL- Bekairy AM (1999). Thymoquinone protects against carbon tetracholide hepatotoxicity in mice via an antioxidant mechanism. Biochem. Mol. Biol. Int. 47:153-159.
Pubmed
 
Najmi A, Nasiruddin M, Khan RA, Haque SF (2008). Effect of Nigella sativa oil on various clinical and biochemical parameters of insulin resistance syndrome. Int. J. Diab. Dev. Ctries. 28:11-14.
Crossref
 
Perveen T, Haider S, Kanwal S, Haleem DJ (2009). "Repeated administration of Nigella sativa decreases 5-HT turnover and produces anxiolytic effects in rats," Pak. J. Pharm. Sci. 22(2):139-144.
Pubmed
 
Rajkapoor B, Anandan R, Jayakar B (1996). Anti-ulcer effect of Nigella sativa and Pongamia pannata in rats. Fitoterapia 67:195-199.
 
Salama RB (1973). Sterols in the seed oil of Nigella sativa. Planta Med. 24(4):375-377.
Crossref
 
Salem EM, Yar T, Bamosa AO, Al-Quorain A, Yasawy MI, Alsulaiman RM, Randhawa MA (2010). Comparative study of Nigella sativa and triple therapy in eradication of Helicobacter Pylori in patients with non-ulcer dyspepsia. Saudi J. Gastroenterol. 16:207-214.
Crossref
 
Salem ML, Hossain MS (2000). Protective effect of black seed oil from Nigella sativa against murine cytomegalovirus infection. Int. J. Immunopharmacol. 22:729-740.
Crossref
 
Salomi MJ, Nair SC, Panikkar KR (1991). Inhibitory effect of Nigella sativa and Saffron (Crocus sativus) on chemical carcinogenesis in mice. Nutr. Cancer 16(1):67-72.
Crossref
 
Salomi NJ, Nair SC, Jayawardhanan KK, Varghese CD, Panikkar KR (1992). Antitumour principles from Nigella sativa seeds. Cancer Lett. 63(1):41-46.
Crossref
 
Staphylakis PK, Gegiou D (1986). The sterols of Nigella sativa seed oil. Phytochem. 25:761-763.
Crossref
 
Tarek El-Naggar, Mar’ıa Pilar G’omez-Serranillos, OlgaMar’ıa P, Carmen A, Mar’ıa EC (2010). Nigella sativa L. Seed Extract Modulates the Neurotransmitter Amino Acids Release in Cultured Neurons in Vitro. J. Biomed. Biotechnol. 2010:398312.
Pubmed
 
Tembhurne SV, Firoj S, Jagtap AG (2008). Nephroprotective activity of Nigella sativa seeds against cisplatin induced Nephrotoxicity in Mice. Indian J. Nat. Prod. 24(1):13-16.
 
Topozada HH, Masloum H, El-Dakhakhany M (1965). The anti-bacterial properties of Nigella sativa seeds: Active principle with some clinical application. J. Egypt Med. Assoc. 48:187-202. Pubmed
 
Worthen DR, Ghosheh OA, Crooks PA (1998). The in vitro anti-tumour activity of some crude and purified components of black-seed, Nigella sativa L. Anticancer Res. 18(3A):1527-1532.
Pubmed
 
Yar T, El-Hariri M, EL-Bahai MN, Bamosa AO (2008). Effects of Nigella sativa supplementation for one month on cardiac reserve in rats. Indian J. Physiol. Pharmacol. 52(2):141-148.
Pubmed
 
Zaoui A, Cherrah Y, Aloui K, Mahassine N, Amarouch H, Hassar M (2002). Effect of Nigella sativa fixed oil on blood homeostasis in rat. J. Ethnopharmacol. 79(1):23-26.
Crossref
 
Zaoui A, Cherrah Y, Mahassine N, Alaoui K, Hassar M (2002). Acute and chronic toxicity of Nigella sativa fixed oil. Phytomedicine 9:69-74.
Crossref
 
Zhou Y, Shen K, Hou S, Qiu M, Luo Z (2003). Experimental study on apoptosis induced by elemene in glioma cells. Ai Zheng. Chin. J. Cancer 22(9):959-963.